Results 71 to 80 of about 13,350 (226)

Spiro[pyrrolidine-3,3′-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes

Molecules, 2017
Synthetic derivatives of spiro[pyrrolidinyl-3,3′-oxindole] alkaloids (coerulescine analogues) were investigated as new ligands for aminergic G-protein coupled receptors (GPCRs).
Ádám A. Kelemen, Grzegorz Satala, Andrzej J. Bojarski, György M. Keserű   +3 more
doaj   +1 more source

Silver(I) triflate-catalyzed protocol for the post-ugi synthesis of spiroindolines

, 2019
A silver(I) triflate-catalyzed protocol for the post-Ugi synthesis of tetracyclic spiroindolines has been developed. The protocol worked best for indole-3-carbaldehyde-derived Ugi adducts obtained using anilines and 3-aryl propiolic acids.
Hasan, Muhammad, Pereshivko, Olga P., Peshkov, Anatoly A., Peshkov, Vsevolod A., Van der Eycken, Erik V., Van Hecke, Kristof, Zaman, Manzoor   +6 more
core   +1 more source

Iridium Complexes of a Triazole‐Derived Pincer Ligand: Synthesis, Reactivity, and Transfer Dehydrogenation Catalysis

Chemistry – A European Journal, EarlyView.
Ir pincer complexes bearing a triazole architecture in the pincer backbone and O‐ancillary chelating ligands are presented. These were employed in the catalytic transfer dehydrogenation of alkanes as well as of saturated heterocycles. Reactivity of these complexes with silver salts and Lewis acids produced various cationic iridium complexes.
Jesvita Cardozo, Ouchan He, Aaron Prenzlow, Xinyang Peng, Kallol Ray, Thomas Braun   +5 more
wiley   +1 more source

Tributylphosphine promoted domino reaction for efficient construction of spiro[cyclohexane-1,3'-indoline] and spiro[indoline-3,2'-furan-3',3''-indoline]

, 2022
Tributylphosphine catalyzed reaction of isatylidene malononitriles and bis-chalcones in chloroform at 65oC afforded the functionalized spiro[cyclohexane-1,3'-indolines] in good yields and with good diastereoselectivity. On the other hand, tributylphosphine catalyzed reaction of 3-(ethoxycarbonylmethylene)oxindoles and bis-chalcones gave functionalized ...
Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan   +3 more
openaire   +1 more source

Total Synthesis of the Spirocyclic Bis‐Indole Alkaloid (−)‐Owerreine via a [4+2] Annulation

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The total synthesis of the bis‐indole alkaloid (−)‐owerreine has been accomplished by a diastereoselective [4+2] annulation between an enamine and an α,β−unsaturated indolenine precursor to form the 3‐spirocyclic tetrahydropyridine linkage of the natural product. DFT calculations allow an understanding of the mechanism of the key annulation.
Elisa Coll, Vincent Gandon, Cyrille Kouklovsky, Laurent Evanno, Guillaume Vincent   +4 more
wiley   +2 more sources

Crystal structure of ethyl 1′,5-dimethyl-2′′,3-dioxo-3H-dispiro[benzo[b]thiophene-2,3′-pyrrolidine-2′,3′′-indoline]-4′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C23H22N2O4S, crystallized with two independent molecules (A and B) in the asymmetric unit. They have very similar conformations with the pyrrolidine ring having a twisted conformation, on the Cspiro—Cspiro bond, in both molecules.
R. Raja, J. Govindaraj, M. Suresh, R. Raghunathan, A. SubbiahPandi   +4 more
doaj   +1 more source

Novel synthesis and characterisation of 3,3-dimethyl-50-(2-benzothiazolyl)- spironaphth(indoline-2,30-[3H]naphth[2,1-b] [1,4]oxazine) derivatives [PDF]

, 2009
Novel modified spirooxazines (SOs) with additional chelating groups were synthesised and the crystal structure of one of these was determined. UV–vis spectroscopic characterization of the photoisomerization of the SO derivatives shows that the ...
Alhashimy, Atabekyan, Baillet, Benkovic, Bertelson, Boeyens, Byrne, Byrne, Cao, Chamonttin, Chu, Clegg, Collins, Crano, Deligeorgiev, Dermot Diamond, Desvergne, Favaro, Feringa, Gőrner, Hirschberg, Irie, Jeliazkova, Kawata, Ko, Le Baccon, Lehn, Lokshin, Löhr, Maeda, Miler-Srenger, Millini, Minkin, Minkovska, Nameer Alhashimy, Nishikiori, Phillips, Pimienta, Pina, Preigh, Radu, Robert Byrne, Rosario, Scarmagnani, Schaffner, Stela Minkovska, Tamai, Tamaki, Taylor, Tian, Uznanski, Wojtyk, Zhou   +52 more
core   +1 more source

Expanded Scorpionate and Siderophore‐Inspired Ligands: From Foundational Designs to Modern Applications

European Journal of Inorganic Chemistry, EarlyView.
The concept of scorpionate ligands has evolved significantly since the introduction of tris(pyrazolyl)borate. By integrating a biological supramolecular ligand scaffold with the classic scorpionate architecture, researchers have made notable strides in mimicking the active sites of nitrogenase and advancing homogeneous catalysis.
Austin Winfield Medley, Trandon Allen Bender   +1 more
wiley   +1 more source

Asymmetric Synthesis of Spirooxindoles via Nucleophilic Epoxidation Promoted by Bifunctional Organocatalysts [PDF]

, 2018
Taking into account the postulated reaction mechanism for the organocatalytic epoxidation of electron-poor olefins developed by our laboratory, we have investigated the key factors able to positively influence the H-bond network installed inside the ...
Abbate, Sergio, Gasperi, Tecla, Longhi, Giovanna, Lupattelli, Paolo, Mazzeo, Giuseppe, Mazziotta, Andrea, Miceli, Martina, Palumbo, Chiara, Roma, Elia, Tosi, Eleonora   +9 more
core   +2 more sources

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source