Results 161 to 170 of about 309,089 (339)

Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells Survive and Integrate into 6-OHDA-Lesioned Rats [PDF]

, 2009
Jingli Cai, Ming Yang, Elizabeth Poremsky, Sarah K. Kidd, Jay S. Schneider, Lorraine Iacovitti   +5 more
openalex   +1 more source

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

Nature, 2011
R. Lister, Mattia Pelizzola, Yasuyuki S. Kida, R. D. Hawkins, Joseph R. Nery, G. Hon, Jessica Antosiewicz-Bourget, Jessica Antosiewicz-Bourget, Ronan C. O’Malley, R. Castanon, Sarit A. Klugman, M. Downes, R. Yu, R. Stewart, R. Stewart, B. Ren, Bing-Jie Ren, J. Thomson, R. Evans, J. Ecker   +19 more
semanticscholar   +1 more source

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

Efficient Adipocyte and Osteoblast Differentiation from Mouse Induced Pluripotent Stem Cells by Adenoviral Transduction [PDF]

, 2009
Katsuhisa Tashiro, Mitsuru Inamura, Kenji Kawabata, Fuminori Sakurai, Koichi Yamanishi, Takao Hayakawa, Hiroyuki Mizuguchi   +6 more
openalex   +1 more source

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

A simple and efficient cryopreservation method for feeder-free dissociated human induced pluripotent stem cells and human embryonic stem cells [PDF]

, 2009
Sepideh Mollamohammadi, A Taei, Mohammad Pakzad, Mehdi Totonchi, Ali Seifinejad, Naser Masoudi, Hossein Baharvand   +6 more
openalex   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

From Code to Life: The AI‐Driven Revolution in Genome Editing

Advanced Science, EarlyView.
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li, Wasi Ullah Khan, Genxiang Bai, Chao Dong, Jungang Wang, Youpeng Zhang, Chong Wang, Hongbin Zhang, Wenyi Wang, Ming Luo, Fei Chen   +10 more
wiley   +1 more source

Enhanced generation of hematopoietic cells from human hepatocarcinoma cell−stimulated human embryonic and induced pluripotent stem cells [PDF]

, 2009
Min Lu, Melanie Kardel, Michael D. O’Connor, Connie J. Eaves   +3 more
openalex   +1 more source

Induced pluripotent stem cells in disease modelling and drug discovery

Nature reviews genetics, 2019
R. G. Rowe, G. Daley
semanticscholar   +1 more source