Induced Pluripotent Stem Cells in Cardiovascular Research
, 2012 The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSC) by overexpression of a combination of transcription factors bears the potential to spawn a wealth of new applications in both preclinical and clinical cardiovascular research.
Ralf J. Dirschinger +5 more
openaire +3 more sources
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, EarlyView.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source
Generation of functional human hepatic endoderm from human induced pluripotent stem cells [PDF]
, 2009 Gareth J. Sullivan +16 more
openalex +1 more source
MRAS: Master Regulator Analysis of Alternative Splicing
Advanced Science, EarlyView.This study developed a computational approach called MRAS, designed to identify master regulators of splicing differences across various biological contexts. In this framework, altered RBP expression, rather than spliceosomal mutations or other modifications, plays a central role in driving these splicing differences.
Lei Zhou +9 more
wiley +1 more source
Generation of Human-Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 [PDF]
, 2009 Wenlin Li +9 more
openalex +1 more source
Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase
Advanced Science, EarlyView.Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo +17 more
wiley +1 more source
Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells Survive and Integrate into 6-OHDA-Lesioned Rats [PDF]
, 2009 Jingli Cai +5 more
openalex +1 more source
The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening
Advanced Science, EarlyView.A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie +5 more
wiley +1 more source
Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins [PDF]
, 2009 Hongyan Zhou +13 more
openalex +1 more source