Results 161 to 170 of about 227,684 (338)
Advanced Science, EarlyView.In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo +19 more
wiley +1 more source
Coating-Free Culture Medium for Establishing and Maintaining Human Induced Pluripotent Stem Cells
, 2023 Chih-Yao Lin +9 more
openalex +1 more source
Advanced Science, EarlyView.Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim +10 more
wiley +1 more source
Reversal of Cellular Phenotypes in Neural Cells Derived from Huntington’s Disease Monkey-Induced Pluripotent Stem Cells [PDF]
, 2014 Richard L. Carter +9 more
openalex +1 more source
MicroRNA-induced pluripotent stem cells [PDF]
, 2014 Chang, Hao-Ming, Gregory, Richard I.
core +1 more source
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Advanced Science, EarlyView.Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source
MicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model [PDF]
Qing Xia +3 more
openalex +1 more source
Advanced Science, EarlyView.This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang +13 more
wiley +1 more source