Results 251 to 260 of about 309,089 (339)

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source

Induced Pluripotent Stem Cells in Cardiomyopathy: Advancing Disease Modeling, Therapeutic Development, and Regenerative Therapy. [PDF]

Int J Mol Sci
Vo QD, Nakamura K, Saito Y, Akagi S, Miyoshi T, Yuasa S.   +5 more
europepmc   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

Editorial: Induced pluripotent stem cells (iPSCs) for skeletal muscle diseases. [PDF]

Front Cell Dev Biol
Sakurai H, Suzuki M, Asakura A.
europepmc   +1 more source

Generation of mouse-induced pluripotent stem cells with plasmid vectors [PDF]

, 2010
Keisuke Okita, Hyenjong Hong, Kazutoshi Takahashi, Shinya Yamanaka   +3 more
openalex   +1 more source

Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response

Advanced Science, EarlyView.
This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li, Jiajun Tan, Chuqing Zhou, Siyi Zhou, Yuanli Ye, Xinzhu Li, Xinyu Shen, Tian Xie, Mengyue Wang, Jingwei Jiang, Yiping Zhao, Xiao Xiang, Yong Zhou, Jun Wu, Cheng‐Ming Chuong, Mingxing Lei   +15 more
wiley   +1 more source

Cytokine-Induced Cytotoxicity and Extracellular Matrix Abnormalities in Hepatocytes Derived From RAD50-Interacting Protein 1-Deficient Induced Pluripotent Stem Cells. [PDF]

FASEB J
Zhang Y, Ogata Y, Nadanaka S, Kitagawa H, Era T, Matsuo M.   +5 more
europepmc   +1 more source

Feeder- and serum-free establishment and expansion of human induced pluripotent stem cells

, 2009
Mehdi Totonchi, Adeleh Taei, Ali Seifinejad, Mohammadsharif Tabebordbar, Hassan Rassouli, Ali Farrokhi, Hamid Gourabi, Nasser Aghdami, Ghasem Hosseini Salekdeh, Hossein Baharvand   +9 more
openalex   +2 more sources

Bioprinted Organoids: An Innovative Engine in Biomedicine

Advanced Science, EarlyView.
Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li, Kai Li, Cheng Zhang, Yingying Zhao, Yiyuan Guo, Jia He, Shiyuan Chang, Xinyi Fang, Kaizheng Liu, Pingping Zhu, Zhenzhen Chen, Changshun Ruan   +11 more
wiley   +1 more source

Erratum: "Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: A Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos". [PDF]

Environ Health Perspect
Nishie T, Taya T, Omori S, Ueno K, Okamoto Y, Higaki S, Oka M, Mitsuishi Y, Tanaka T, Nakamoto M, Kawahara H, Teraguchi N, Kotaka T, Sawabe M, Takahashi M, Kitaike S, Wada M, Iida K, Yamashita A, Jinno H, Ichimura A, Tooyama I, Sakai N, Hibi M, Hirasawa A, Takada T.   +25 more
europepmc   +1 more source