Results 271 to 280 of about 496,668 (364)

Pharmacological Inhibition of β Myosin II Disrupts Sarcomere Assembly in Human iPSC‐Derived Cardiac Myocytes

Cytoskeleton, EarlyView.
ABSTRACT Sarcomeres are the fundamental contractile units of striated muscle. The functional roles of the cardiac‐specific myosin heavy chains, MYH6 (α myosin II) and MYH7 (β myosin II) during sarcomere assembly remain controversial. To address this, we utilized a selective MYH7 inhibitor, mavacamten, in combination with siRNA‐mediated knockdown of ...
James B. Hayes, Dylan T. Burnette
wiley   +1 more source

Cell Seeding Strategy Influences Metabolism and Differentiation Potency of Human Induced Pluripotent Stem Cells Into Pancreatic Progenitors. [PDF]

Biotechnol J
Huang H, Ye K, Jin S.
europepmc   +1 more source

Enhanced Generation of Induced Pluripotent Stem Cells from a Subpopulation of Human Fibroblasts

, 2009
James Byrne, Ha Nam Nguyen, Renee A. Reijo Pera   +2 more
openalex   +2 more sources

Induced Pluripotent Stem Cells Can Be Used to Model the Genomic Imprinting Disorder Prader-Willi Syndrome [PDF]

, 2010
Jiayin Yang, Jie Cai, Zhang Ya, Xianming Wang, Wen Li, Jianyong Xu, Feng Li, Xiangpeng Guo, Kang Deng, Mei Zhong, Yonglong Chen, Liangxue Lai, Duanqing Pei, Miguel A. Esteban   +13 more
openalex   +1 more source

Enhancing WRAP‐Based Nanoparticles for Small Interfering Ribonucleic Acid Delivery in pH‐Sensitive Environments

ChemMedChem, EarlyView.
PEGylation of the WRAP5‐based nanoparticles via acyl hydrazone linkers is achieved to obtain a pH‐sensitive small interfering ribonucleic acid‐targeted delivery. In acidic extracellular conditions (pH 5) occurring during myocardial ischemia‐reperfusion injury, this optimized delivery system is the only one showing efficient silence of the Fas ...
Giulia Di Gregorio, Coélio Vallée, Karidia Konate, Clémentine A. Teko‐Agbo, Thania Hammoum, Héloïse Faure‐Gautron, Yannick Bessin, Sebastien Deshayes, Eric Vivès, Albano C. Meli, Pascal de Santa Barbara, Sandrine Faure, Stéphanie Barrère‐Lemaire, Sébastien Ulrich, Prisca Boisguérin   +14 more
wiley   +1 more source

Robust generation of photoreceptor-dominant retinal organoids from porcine induced pluripotent stem cells. [PDF]

Stem Cell Reports
Edwards KL, Moore BM, Ganser TS, Susaimanickam PJ, Sovell K, Martin Y, Jager LD, Willes AM, Moyer TH, Bowar L, Phillips MJ, Stewart R, Chu LF, Gamm DM.   +13 more
europepmc   +1 more source

Reprogramming the pluripotent cell cycle: Restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells [PDF]

, 2010
Prachi N. Ghule, Ricardo Medina, Christopher J. Lengner, Matthew Mandeville, Meng Qiao, Zbigniew Domiński, Jane B. Lian, Janet L. Stein, André J. van Wijnen, Gary S. Stein   +9 more
openalex   +1 more source

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

Expression Patterns of Escape Genes in Turner Syndrome Fibroblasts and Induced Pluripotent Stem Cells. [PDF]

Int J Mol Sci
Byun S, Yoon SH, Hong YJ, Jang HS, Seo BJ, Choi GT, La H, Lee JW, Hong K, Do JT.   +9 more
europepmc   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source