Results 41 to 50 of about 227,684 (338)

Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons? [PDF]

, 2013
Heart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the ...
Liao, S, Tse, HF
core   +2 more sources

Induced pluripotent stem (iPS) cells from human fetal stem cells [PDF]

, 2016
Pluripotency defines the ability of stem cells to differentiate into all the lineages of the three germ layers and self-renew indefinitely. Somatic cells can regain the developmental potential of embryonic stem cells following ectopic expression of a set
Guillot, PV
core   +1 more source

Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

Haematologica, 2010
Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne, Ladan Kobari, Christelle Mazurier, Philippe Tropel, Marie-Catherine Giarratana, Isabelle Zanella-Cleon, Laurent Kiger, Marie Wattenhofer-Donzé, Hélène Puccio, Nicolas Hebert, Alain Francina, Georges Andreu, Stéphane Viville, Luc Douay   +13 more
doaj   +1 more source

Vitamin C promotes the early reprogramming of fetal canine fibroblasts into induced pluripotent stem cells

Journal of Animal Reproduction and Biotechnology, 2023
Background: Canine induced pluripotent stem cells (iPSCs) are an attractive source for veterinary regenerative medicine, disease modeling, and drug development.
Sang Eun Kim, Jun Sung Lee, Keon Bong Oh, https://orcid.org/0000-0002-0651-0306   +3 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

DNA Methylation Is Involved in the Expression of miR-142-3p in Fibroblasts and Induced Pluripotent Stem Cells

Stem Cells International, 2014
MicroRNAs are differentially expressed in cells and regulate multiple biological processes. We have been analyzing comprehensive expression patterns of microRNA in human and mouse embryonic stem and induced pluripotent stem cells. We determined microRNAs
Siti Razila Abdul Razak, Yukihiro Baba, Hiromitsu Nakauchi, Makoto Otsu, Sumiko Watanabe   +4 more
doaj   +1 more source

Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity

SAGE Open Medicine, 2020
Objectives: To establish a straightforward single-cell passaging cultivation method that enables high-quality maintenance of human induced pluripotent stem cells without the appearance of karyotypic abnormalities or loss of pluripotency.
Estela Cruvinel, Isabella Ogusuku, Rosanna Cerioni, Sirlene Rodrigues, Jéssica Gonçalves, Maria Elisa Góes, Juliana Morais Alvim, Anderson Carlos Silva, Vanesca de Souza Lino, Enrique Boccardo, Ernesto Goulart, Alexandre Pereira, Rafael Dariolli, Marcos Valadares, Diogo Biagi   +14 more
doaj   +1 more source

Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]

, 2016
Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P, Byrne, James A, Chang, Katherine M, Hermann, Kip J, Lee, Patrick C, Lipshutz, Gerald S, Schoenberg, Benjamen E, Truong, Brian, Vega-Crespo, Agustin, Wu, Lily   +9 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Advances in human stem cell therapies: pre-clinical studies and the outlook for central nervous system regeneration

Neural Regeneration Research, 2021
Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical settings. There are several types of stem cells currently being used for pre-clinical regenerative
Lindsey H Forbes, Melissa R Andrews
doaj   +1 more source