Results 41 to 50 of about 496,668 (364)
Induced Pluripotent Stem Cells
Cell Transplantation, 2018 Many neurodegenerative diseases are progressive, complex diseases without clear mechanisms or effective treatments. To study the mechanisms underlying these diseases and to develop treatment strategies, a reliable in vitro modeling system is critical ...
Chia-Yu Chang +6 more
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DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]
PLoS ONE, 2012 The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo +7 more
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Cell reprogramming modelled as transitions in a hierarchy of cell cycles [PDF]
J. Phys. A: Math. Theor. 50 (2017) 425601 (23pp), 2016 We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing ...
arxiv +1 more source
A pathologist's perspective on induced pluripotent stem cells [PDF]
Laboratory Investigation, 2017 Induced pluripotent stem cell (iPSC) technology was originally developed in 2006. Essentially, it converts somatic cells into pluripotent stem cells by transiently expressing a few transcriptional factors. Once generated, these iPSCs can differentiate into all the cell types of our body, theoretically, which has attracted great attention for clinical ...
Noriko Watanabe +3 more
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Data in Brief, 2021 Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripotent ...
Anja Patricia Ramme +4 more
doaj
Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation [PDF]
, 2015 Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential to the reprogramming of cells for biomedical applications, i.e., the experimental recovery of ...
arxiv +1 more source
Stem cell research & therapeutics, 2019 Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not exist naturally and are instead generated (“induced” or “reprogrammed”) in culture from ...
S. Moradi +7 more
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SAGE Open Medicine, 2020 Objectives: To establish a straightforward single-cell passaging cultivation method that enables high-quality maintenance of human induced pluripotent stem cells without the appearance of karyotypic abnormalities or loss of pluripotency.
Estela Cruvinel +14 more
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A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells [PDF]
arXiv, 2021 Human pluripotent stem cells (hPSCs) have promising clinical applications in regenerative medicine, drug-discovery and personalised medicine due to their potential to differentiate into all cell types, a property know as pluripotency. A deeper understanding of how pluripotency is regulated is required to assist in controlling pluripotency and ...
arxiv
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
Nature, 2012 Our understanding of Alzheimer’s disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease.
Mason A. Israel +16 more
semanticscholar +1 more source