Results 41 to 50 of about 398,685 (377)
Mouse induced pluripotent stem cells
The International Journal of Developmental Biology, 2008 The recent discovery that it is possible to directly reprogramme somatic cells to an embryonic stem (ES) cell-like pluripotent state, by retroviral transduction of just four genes (Oct3/4, Sox2, c-Myc and Kif4), represents a major breakthrough in stem cell research.
Geoghegan, Eamon, Byrnes, Lucy
openaire +5 more sources
Induced Pluripotent Stem Cells at Nanoscale [PDF]
Stem Cells and Development, 2010 Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been made possible with the expression of the transcription factor quartet Oct4, Sox2, c-Myc, and Klf4. Here, we compared iPS cells derived from mouse embryonic fibroblasts with the 4 factors to embryonic stem cells by electron microscopy.
Dagmar Zeuschner +3 more
openaire +3 more sources
Сибирский научный медицинский журнал, 2019 Stem cells are divided into embryonic and adult stem cells. The relevance of the use of stem cells in clinical practice has received new evidence in recent years however, the methods of obtaining stem cells for medical purposes cause ethical rejection ...
A. V. Korel, S. B. Kuznetsov
doaj +1 more source
Frontiers in Genetics, 2022 Pluripotency is a transient state in early embryos, which is regulated by an interconnected network of pluripotency-related genes. The pluripotent state itself seems to be highly dynamic, which leads to significant differences in the description of ...
Huajin Li +17 more
doaj +1 more source
Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]
, 2017 Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J +15 more
core +3 more sources
Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro
Frontiers in Cell and Developmental Biology, 2020 Neural stem cells (NSCs) provide promising approaches for investigating embryonic neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and for designing drug-screening systems.
A. A. Galiakberova, E. Dashinimaev
semanticscholar +1 more source
Editorial: Reviews in induced pluripotent stem cells
Frontiers in Cell and Developmental Biology, 2023 No abstract ...
Mirella Dottori +5 more
openaire +6 more sources
Establishment of Bovine-Induced Pluripotent Stem Cells [PDF]
International Journal of Molecular Sciences, 2021 Pluripotent stem cells (PSCs) have been successfully developed in many species. However, the establishment of bovine-induced pluripotent stem cells (biPSCs) has been challenging. Here we report the generation of biPSCs from bovine mesenchymal stem cells (bMSCs) by overexpression of lysine-specific demethylase 4A (KDM4A) and the other reprogramming ...
Yue Su +11 more
openaire +2 more sources
Organoids in domestic animals: with which stem cells?
Veterinary Research, 2021 Organoids are three-dimensional structures that are derived from the self-organization of stem cells as they differentiate in vitro. The plasticity of stem cells is one of the major criteria for generating organoids most similar to the tissue structures ...
Bertrand Pain
doaj +1 more source
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
core +2 more sources