Mechanisms underlying the protective effects of San‐Bai decoction against UV radiation on the skin
International Journal of Cosmetic Science, EarlyView.Combining conventional differential expression analysis with differential network analysis offers a promising strategy to uncover the mechanistic basis of the holistic benefits provided by herbal blends. Our findings demonstrated that San‐Bai decoction modulates multiple pathways—not only those related to skin pigmentation, such as ET‐1 signalling, but
Rui Zhang +7 more
wiley +1 more source
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. [PDF]
, 2014 Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm.
Blazar, Bruce +18 more
core +1 more source
Amniotic Epithelial Cells: A New Tool to Combat Aging and Age-Related Diseases? [PDF]
, 2016 The number of elderly people is growing at an unprecedented rate and this increase of the aging population is expected to have a direct impact on the incidence of age-related diseases and healthcare-associated costs. Thus, it is imperative that new tools
Barbara Barboni +4 more
core +2 more sources
Immunology &Cell Biology, EarlyView.Sustained IL‐2 production delays T follicular helper cell differentiation and germinal center formation but does not alter final antibody titers or antigen‐specific humoral immunity after vaccination. Created in BioRender. Burton, A. (2026) https://BioRender.com/paggz41 Abstract Vaccines stimulate protective humoral immunity by coordinating lymphocyte ...
Silvia Innocentin +9 more
wiley +1 more source
Role of inflammaging in the development of chronic heart failure and osteoporosis: A literature review [PDF]
КардиоСоматикаThe interaction between heart failure (HF) and osteoporosis in a multimorbid patient is a relevant complication in the aging population. The concept of inflammaging (inflammatory aging) allows us to consider the prolonged process of subclinical ...
Vera N. Larina, Ekaterina S. Shcherbina
doaj +1 more source
CD24 enrichment protects while its loss increases susceptibility of juvenile chondrocytes towards inflammation [PDF]
, 2016 Supplemental methods.
Jason Dragoo +4 more
core +2 more sources
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth +5 more
wiley +1 more source
Inflammaging, immunosenescence, and cardiovascular aging: insights into long COVID implications
Frontiers in Cardiovascular MedicineAging leads to physiological changes, including inflammaging—a chronic low-grade inflammatory state with significant implications for various physiological systems, particularly for cardiovascular health.
Ludmila Müller, Svetlana Di Benedetto
doaj +1 more source
Mediators of Inflammation, 2017 A relevant feature of aging is chronic low-grade inflammation, termed inflammaging, a key process promoting the development of all major age-related diseases.
Angelica Giuliani +5 more
doaj +1 more source
Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes. [PDF]
, 2013 Factor structure analyses have revealed the presence of specific biological system markers in healthy humans and diseases. However, this type of approach in very old persons and in type 2 diabetes (T2DM) is lacking.
Abbatecola, AM +17 more
core +1 more source