Results 211 to 220 of about 17,832 (233)
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Gerontology, 2019
Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated ...
Tamàs, Fülöp +2 more
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Human aging is a very complex process that occurs in an intricate biological and physiological setting. Many changes occur with aging and among the most important are changes in immune reactivity associated with cell differentiation stages and the phenomenon of inflammaging, understood as subclinical inflammatory readiness, manifested by elevated ...
Tamàs, Fülöp +2 more
openaire +2 more sources
Journal of Investigative Dermatology, 2021
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed
Suzanne M. Pilkington +3 more
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As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of circulating proinflammatory cytokines and a shift toward cellular senescence, changes that are believed
Suzanne M. Pilkington +3 more
openaire +2 more sources
Current Opinion in Clinical Nutrition & Metabolic Care, 2017
Immunosenescence has been scrutinized in detail, and evidence that inflammation and ageing are interrelated is consistent. Still, a gold standard for assessing the biological age of the immune function in an individual patient is lacking, so that immunosenescence is still not a quantifiable criterion in clinical decision-making processes.This review ...
Ursula, Müller-Werdan +2 more
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Immunosenescence has been scrutinized in detail, and evidence that inflammation and ageing are interrelated is consistent. Still, a gold standard for assessing the biological age of the immune function in an individual patient is lacking, so that immunosenescence is still not a quantifiable criterion in clinical decision-making processes.This review ...
Ursula, Müller-Werdan +2 more
openaire +2 more sources
Bladder cancer, inflammageing and microbiomes
Nature Reviews Urology, 2022Ageing is correlated with elevated bladder cancer incidence, morbidity and mortality. Advanced age is also associated with elevated markers of chronic inflammation and perturbations in gut and urinary tract microbiota. One reason for the increased incidence and mortality of bladder cancer in the elderly might be that age-associated changes in multiple ...
Martin, Austin +4 more
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Ammonia-Induced Glial-Inflammaging
Molecular Neurobiology, 2020Astrocytes are functionally diverse glial cells that maintain blood-brain barrier (BBB) integrity, provide metabolic and trophic support, and react to pathogens or harmful stimuli through inflammatory response. Impairment of astrocyte functions has been implicated in hepatic encephalopathy (HE), a neurological complication associated with ...
Larissa Daniele Bobermin +3 more
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2019
Inflammaging refers to the chronic, low-grade inflammation that develops with age and may favor the onset of age-related diseases (ARDs) and geriatric syndromes (GSs). Many molecular mechanisms are involved in causing inflammaging, from innate immunity activation to increased availability of DAMPs and to mitochondria-ER stress. Inflammaging is emerging
Capri M., Franceschi C., Salvioli S.
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Inflammaging refers to the chronic, low-grade inflammation that develops with age and may favor the onset of age-related diseases (ARDs) and geriatric syndromes (GSs). Many molecular mechanisms are involved in causing inflammaging, from innate immunity activation to increased availability of DAMPs and to mitochondria-ER stress. Inflammaging is emerging
Capri M., Franceschi C., Salvioli S.
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Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity
Archivum Immunologiae et Therapiae Experimentalis, 2015Longevity and aging are two sides of the same coin, as they both derive from the interaction between genetic and environmental factors. Aging is a complex, dynamic biological process characterized by continuous remodeling. One of the most recent theories on aging focuses on immune response, and takes into consideration the activation of subclinical ...
MINCIULLO, PAOLA LUCIA +9 more
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Nihon rinsho. Japanese journal of clinical medicine, 2019
Chronic inflammation is the common pathological basis for age-associated diseases. Chronic activation of basic inflammatory sates is known to associate with aging. Changes in immune system (immunosenescence), tissue microenvironment, such as the accumulation of cell debris, and systemic changes in metabolic and hormonal signals, likely contribute to ...
Yumiko, Oishi, Ichiro, Manabe
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Chronic inflammation is the common pathological basis for age-associated diseases. Chronic activation of basic inflammatory sates is known to associate with aging. Changes in immune system (immunosenescence), tissue microenvironment, such as the accumulation of cell debris, and systemic changes in metabolic and hormonal signals, likely contribute to ...
Yumiko, Oishi, Ichiro, Manabe
openaire +1 more source
NLRP3 inflammasome activation in inflammaging
Seminars in Immunology, 2018The process of aging is associated with the appearance of low-grade subclinical inflammation, termed inflammaging, that can accelerate age-related diseases. In Western societies the age-related inflammatory response can additionally be aggravated by an inflammatory response related to modern lifestyles and excess calorie consumption, a pathophysiologic
Latz, Eicke, Duewell, Peter
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Inflammaging aggravates stroke pathology
Nature Immunology, 2023Christian Schulz, Steffen Massberg
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