Results 191 to 200 of about 197,632 (380)

Magnesium-enriched deep-sea water inhibits NLRP3 inflammasome activation and dampens inflammation

Heliyon
The NLRP3 inflammasome is an essential component of the innate immune system, but excessive activation can lead to inflammatory diseases. Ion fluxes across the plasma membrane or from intracellular stores are known to regulate NLRP3 inflammasome ...
Hsueh-Hsiao Wang, Chi-Ruei Huang, Hsin-Chung Lin, Hsin-An Lin, Yu-Jen Chen, Kuen-Jou Tsai, Chieh-Tien Shih, Kuo-Yang Huang, David M. Ojcius, Ming-Hang Tsai, Kuang-Wen Tseng, Lih-Chyang Chen   +11 more
doaj   +1 more source

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

, 2004
Laetitia Agostini, Fabio Martinon, Kimberly Burns, Michael McDermott, Philip N. Hawkins, Jürg Tschopp   +5 more
openalex   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Autophagy Gives a Nod and a Wink to the Inflammasome and Paneth Cells in Crohn's Disease [PDF]

, 2008
Vojo Deretić, Sharon Master, Sudha Singh   +2 more
openalex   +1 more source

Hepatocyte‐Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non‐Canonical Secretion of Anti‐Inflammatory Factors

Advanced Science, EarlyView.
This study proposes for the first time that hepatic GSDMD plays a key protective role in sepsis. Hepatic GSDMD may release inflammatory inhibitory factors including VEGF‐B and Gremlin‐1 through pore‐forming activity to inhibit the production of inflammatory factors from macrophages, thereby alleviating the inflammatory response of septic mice ...
Yihan Qian, Bingrui Wang, Chang Yu, Yuge Zhou, Weifan Huang, Xing Rong, Yali Sang, Jiangang Song, Hailong Wu, Xiaoni Kong   +9 more
wiley   +1 more source

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

Molecules and Cells, 2002
F. Martinon, K. Burns, J. Tschopp
semanticscholar   +1 more source

Novel Role of Gut‐Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure

Advanced Science, EarlyView.
Arsenic exposure disrupts intestinal barriers and gut microenvironment. Fecal microbiota transplantation (FMT) alleviates arsenic‐induced damage, with gut‐derived Roseburia intestinalis (R.i) identified as a key protective strain. R.i administration counters arsenic toxicity through immunomodulatory pathways and metabolites.
Lixiao Zhou, Chunsong Wang, Jieying Gao, Xu Wu, Geng Li, Xuejun Jiang, Yinyin Xia, Jun Zhang, Bo Lv, Feng Zhao, Hongyang Zhang, Huifeng Pi, Jingfu Qiu, Shangcheng Xu, Zhen Zou, Chengzhi Chen   +15 more
wiley   +1 more source

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

Nature, 2021
T. Fidler, Chenyi Xue, M. Yalcinkaya, B. Hardaway, Sandra Abramowicz, Tong Xiao, Wenli Liu, D. G. Thomas, M. Hajebrahimi, J. Pircher, C. Silvestre-Roig, Andriana G Kotini, Larry L. Luchsinger, Ying Wei, M. Westerterp, H. Snoeck, E. Papapetrou, C. Schulz, S. Massberg, O. Soehnlein, B. Ebert, R. Levine, M. Reilly, P. Libby, Nan Wang, A. Tall   +25 more
semanticscholar   +1 more source

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

Advanced Science, EarlyView.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan, Yuyu Li, Shuo Chen, Li Zhu, Chenchen Zhou, Jianwei Chen, Shujuan Zou, Xianglong Han   +7 more
wiley   +1 more source

Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation [PDF]

, 2009
Luigi Franchi, Tatjana Eigenbrod, Gabriel Núñez   +2 more
openalex   +1 more source