Results 221 to 230 of about 190,243 (379)

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo   +10 more
wiley   +1 more source

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues [PDF]

open access: green, 2009
Yong Yin   +6 more
openalex   +1 more source

Mechanism and Regulation of NLRP3 Inflammasome Activation.

open access: yesTIBS -Trends in Biochemical Sciences. Regular ed, 2016
Yuan He, H. Hara, G. Núñez
semanticscholar   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

open access: yesAdvanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong   +12 more
wiley   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

open access: yesAdvanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei   +10 more
wiley   +1 more source

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans [PDF]

open access: bronze, 2009
Amy G. Hise   +6 more
openalex   +1 more source

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

open access: yesNature Network Boston, 2015
Rebecca C. Coll   +21 more
semanticscholar   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

open access: yesAggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang   +6 more
wiley   +1 more source

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