Results 261 to 270 of about 197,632 (380)

Transcriptional and inflammasome‐mediated pathways for the induction of IL‐1β production by Mycobacterium tuberculosis

, 2009
Johanneke Kleinnijenhuis, Leo A. B. Joosten, Frank L. van de Veerdonk, Nigel D. L. Savage, Reinout van Crevel, Bart Jan Kullberg, André van der Ven, Tom H. M. Ottenhoff, Charles A. Dinarello, J.W.M. van der Meer, Mihai G. Netea   +10 more
openalex   +1 more source

Chemical probing reveals insights into the signaling mechanism of inflammasome activation [PDF]

, 2010
Yi‐Nan Gong, Xiaoming Wang, Jiayi Wang, Zhenxiao Yang, Shan Li, Jieling Yang, Liping Liu, Xiaoguang Lei, Feng Shao   +8 more
openalex   +1 more source

Oxidative Stress Modulation and Antileishmanial Activity of Salvinia auriculata

Chemistry &Biodiversity, EarlyView.
Ethanolic extract of Salvinia auriculata showed significant antioxidant and antileishmanial activities. Salviniside II, the major metabolite, was isolated, structurally characterized, and evaluated, but exhibited weaker antiparasitic effects when compared to the whole extract.
Augusto César Rodrigues, Emilha Uzum Papaya, Fernanda da Silva, Carla Cardozo Pinto de Arruda, Edson Lucas dos Santos, Kely de Picoli Souza, Carlos Alexandre Carollo   +6 more
wiley   +1 more source

The Flavonoid Kaempferol Mitigates Periprosthetic Osteolysis by Regulating the NLRP3 Inflammasome and Balancing Bone Metabolism. [PDF]

J Cell Mol Med
Huang C, Zhang C, Luo Y, Guo L, Wu Y, Shi Q, Zhang Y, Yang C, Wang B, Niu J, Lin J.   +10 more
europepmc   +1 more source

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Nature Immunology, 2008
V. Hornung, F. Bauernfeind, A. Halle, E. Samstad, H. Kono, K. Rock, K. Fitzgerald, E. Latz   +7 more
semanticscholar   +1 more source

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

Probenecid relieves LPS-induced neuroinflammation by modulating the NLRP1 inflammasome pathway in BV2 cells. [PDF]

Sci Rep
Wang X, Tian H, Chen S, Ying L, Zheng J, Song Y, Xi J, Zhang Y, Wang D.   +8 more
europepmc   +1 more source

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

, 2009
Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P. Lee, Hal M. Hoffman, Vishva M. Dixit   +8 more
openalex   +2 more sources

Activation of the NLRP3 inflammasome by intracellular poly I:C [PDF]

, 2010
Jayant V. Rajan, Sarah Warren, Edward A. Miao, Alan Aderem   +3 more
openalex   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source