Results 261 to 270 of about 190,243 (379)

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome [PDF]

, 2010
Christian Bauer, Peter Duewell, Christine Mayer, Hans A. Lehr, Katherine A. Fitzgerald, M Dauer, J Tschopp, Stefan Endres, Eicke Latz, Max Schnurr   +9 more
openalex   +1 more source

Enhancing antitumor immunity through the combination of cholesterolized TLR7 agonist liposomes and radiotherapy: a role for IL‐1β and the inflammasome pathway

Cancer Communications, EarlyView.
Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han, Yuan Cheng, Dandan Wan, Aqu Alu, Ziqi Zhang, Zhenfei Bi, Manni Wang, Yan Tang, Weiqi Hong, Siyuan Chen, Li Chen, Yuquan Wei   +11 more
wiley   +1 more source

Pyroptosis, a double-edged sword during pathogen infection: a review. [PDF]

Cell Death Discov
Zhang Y, Zhao D, Wang T, Li P, Yu D, Gao H, Zhao M, Qin L, Zhang K.   +8 more
europepmc   +1 more source

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Cancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan, Jinsong Xu, Zhanqiao Zhang, Yating Hu, Yongsheng Li, Junying Qian, Yunyan Ling, Dehua Wu, Haijun Deng, Guoxin Li, Zhiyong Shen, Yuan Fang   +11 more
wiley   +1 more source

ACPA-Induced ATP release and K⁺ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis. [PDF]

Cell Commun Signal
Cai L, Zhang K, Gao J, Xiao B, Li M, Meng X, Chen Z, Chen X, Chen S, Li J.   +9 more
europepmc   +1 more source

NLRP3 inflammasome activation drives tau pathology

Nature, 2019
Christina Ising, C. Venegas, Shuangshuang Zhang, H. Scheiblich, S. Schmidt, A. Vieira-Saecker, S. Schwartz, Shadi Albasset, R. McManus, Darío Tejera, A. Griep, Francesco Santarelli, F. Brosseron, S. Opitz, James Stunden, Maximilian Merten, R. Kayed, D. Golenbock, D. Blum, E. Latz, L. Buée, M. Heneka   +21 more
semanticscholar   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy. [PDF]

Sci Rep
Chen C, Xie Z, Ao D, Chen Y, Liu L, Li C.   +5 more
europepmc   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Dead or alive: how the immune system detects microbial viability

, 2019
Sander, L., Ugolini, M.
core   +1 more source