Results 51 to 60 of about 197,632 (380)

AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection

Virulence, 2022
NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection.
Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li, Xulin Chen, Zhixin Liu, Qiwei Zhang, Zhen Luo, Jianguo Wu   +14 more
doaj   +1 more source

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Nature Communications, 2021
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism
Pan Pan, Miaomiao Shen, Zhen-Dong Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pinjun Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li, Jianguo Wu   +21 more
semanticscholar   +1 more source

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

Acta Pharmaceutica Sinica B, 2019
Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic ...
Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li, Ming Niu, Jiabo Wang, Youping Liu, Xiaohe Xiao, Zhaofang Bai   +11 more
doaj   +1 more source

Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease

EMBO Molecular Medicine, 2021
The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation.
Daisuke Watanabe, Yijie Guo, Nobuhiko Kamada   +2 more
doaj   +1 more source

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]

, 2015
Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky, Demon, Dieter, Janssens, Sophie, Lamkanfi, Mohamed, Lornet, Guillaume, Timmerman, Vincent, Ydens, Elke   +6 more
core   +2 more sources

Inflammasome activation in infected macrophages drives COVID-19 pathology

Nature, 2021
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated and required for pathology in the SARS-CoV-2-infected MISTRG6-hACE2 ...
Esen Sefik, Rihao Qu, Caroline Junqueira, Eleanna Kaffe, H. Mirza, Jun Zhao, J. R. Brewer, Ailin Han, H. Steach, Benjamin Israelow, Holly N Blackburn, Sofia E. Velazquez, Y. G. Chen, Stephanie Halene, A. Iwasaki, E. Meffre, M. Nussenzweig, J. Lieberman, Craig B. Wilen, Y. Kluger, R. Flavell   +20 more
semanticscholar   +1 more source

Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation [PDF]

, 2016
Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis-associated inflammation. This study aims to assess in acute coronary syndrome (ACS) patients (
Christina Bursill, Cloe A Payet, David S Celermajer, Gonzalo J Martínez, Jennifer Y Barraclough, Sanjay Patel, Stacy Robertson, † ‡, † ‡   +8 more
core   +1 more source

Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production

Scientific Reports, 2017
Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation,
Huijeong Ahn, Eunsaem Jeon, Jin-Chul Kim, Seung Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Pyeung-Hyeun Kim, Geun-Shik Lee   +7 more
doaj   +1 more source

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2021
Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of innate immune responses, but improper and excessive activation can cause inflammatory disease.
Hsin-Chung Lin, Hsin-Chung Lin, Yu-Jen Chen, Yu-Jen Chen, Yu-Jen Chen, Yau-Huei Wei, Hsin-An Lin, Chien-Chou Chen, Tze-Fan Liu, Yi-Lin Hsieh, Kuo-Yang Huang, Kuan-Hung Lin, Hsueh-Hsiao Wang, Lih-Chyang Chen   +13 more
doaj   +1 more source

Inflammasome activation at the crux of severe COVID-19

Nature reviews. Immunology, 2021
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as obesity and diabetes.
Setu M. Vora, J. Lieberman, Hao Wu
semanticscholar   +1 more source