Results 51 to 55 of about 6,721 (55)

Immunogenic cell death triggered by pathogen ligands via host germ line-encoded receptors [PDF]

arXiv
The strategic induction of cell death serves as a crucial immune defense mechanism for the eradication of pathogenic infections within host cells. Investigating the molecular mechanisms underlying immunogenic cell pathways has significantly enhanced our understanding of the host's immunity.
arxiv  

ER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation

eLife
We studied lysosomal Ca2+ in inflammasome. Lipopolysaccharide (LPS) + palmitic acid (PA) decreased lysosomal Ca2+ ([Ca2+]Lys) and increased [Ca2+]i through mitochondrial ROS, which was suppressed in Trpm2-KO macrophages.
Hyereen Kang, Seong Woo Choi, Joo Young Kim, Soo-Jin Oh, Sung Joon Kim, Myung-Shik Lee   +5 more
doaj   +1 more source

Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses

Immunity & Ageing
Aging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of inflammation is multifactorial and is driven by numerous inflammatory pathways, including the inflammasome.
Sarah Talley, Tyler Nguyen, Lily Van Ye, Rasa Valiauga, Jake DeCarlo, Jabra Mustafa, Benjamin Cook, Fletcher A. White, Edward M. Campbell   +8 more
doaj   +1 more source

Inflammasomes, neutrophil extracellular traps, and cholesterol

Journal of Lipid Research, 2019
Activation of macrophage inflammasomes leads to interleukin (IL)-1β and IL-18 secretion and promotes atherosclerosis and its complications in mice and humans.
Alan R. Tall, Marit Westerterp
doaj  

Vanillylacetone attenuates NLRP3 inflammasome mediated immune responses in murine bone marrow derived macrophages via NLRP3 alkylation

Journal of Functional Foods, 2020
Vanillylacetone (VA) is widely used as a food additive owing to its sweet flavour. In this study, we have reported for the first time that VA has an inhibitory role in inflammasome activation.
Han-Bi Kim, Sang-Chul Kwon, Xiao Sun, Mahbuba Akther, Jun-Hyuk Han, Tae-Yeon Kim, Tae-Bong Kang, Kwang-Ho Lee   +7 more
doaj