Results 211 to 220 of about 56,139 (234)
Broad-spectrum inflammasome inhibition by thiomuscimol. [PDF]
Cell Death DiscovAnderson MJ +3 more
europepmc +1 more source
Pyroptosis: molecular mechanisms and roles in disease. [PDF]
Cell ResBroz P.
europepmc +1 more source
Inflammasomes in Alzheimer's Progression: Nrf2 as a Preventive Target. [PDF]
Antioxidants (Basel)López-Hernández R +5 more
europepmc +1 more source
The Evolution of NLR Inflammasome and Its Mediated Pyroptosis in Metazoa. [PDF]
Int J Mol SciSun J, Leng J, Song L.
europepmc +1 more source
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Developmental & Comparative Immunology, 2021
Since inflammasomes were discovered in the early 21st century, knowledge about their biology has multiplied exponentially. These cytosolic multiprotein complexes alert the immune system about the presence of infection or tissue damage, and regulate the subsequent inflammatory responses.
Victoriano Mulero +2 more
openaire +3 more sources
Since inflammasomes were discovered in the early 21st century, knowledge about their biology has multiplied exponentially. These cytosolic multiprotein complexes alert the immune system about the presence of infection or tissue damage, and regulate the subsequent inflammatory responses.
Victoriano Mulero +2 more
openaire +3 more sources
Molecular Aspects of Medicine, 2022
Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
openaire +3 more sources
Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
openaire +3 more sources
Inflammasome and Atherogenesis
Current Pharmaceutical Design, 2014Atherosclerosis is a progressive disease starting with accumulation of lipids, lipoproteins, and immune cells in the arterial wall. Inflammation and the innate immune response are involved in the formation of early atherosclerotic lesion. A protein complex known as the inflammasome is stimulated to activate interleukin-1β (IL-1β) and IL-18, which are ...
Vijay Kakkar, Xinjie Lu
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Molecular Immunology, 2017
Autophagy is a ubiquitous cellular mechanism for the targeted lysosomal degradation of various cytosolic constituents, from proteins to organelles. As an essential homeostatic mechanism, autophagy is upregulated in response to numerous environmental and pharmacological stimuli, including starvation, where it facilitates the recycling of essential amino
Tali Lang +5 more
openaire +3 more sources
Autophagy is a ubiquitous cellular mechanism for the targeted lysosomal degradation of various cytosolic constituents, from proteins to organelles. As an essential homeostatic mechanism, autophagy is upregulated in response to numerous environmental and pharmacological stimuli, including starvation, where it facilitates the recycling of essential amino
Tali Lang +5 more
openaire +3 more sources
Quieting the inflammasome [PDF]
Nature Reviews Immunology, 2012 Autophagosome formation accompanies inflammasome activation and acts to limit inflammasome activity.
openaire +2 more sources