Results 201 to 210 of about 45,312 (295)

Evaluation of ASC as a therapeutic target for Alzheimer's disease. [PDF]

Alzheimers Dement
Clayton WB, Kulas JA, Liu J, Walia N, Rangel-Barajas C, Johnson T, Zhang J, Huang K, Mesecar AD, Dage JL, Lamb BT, Palkowitz AD, Richardson TI.   +12 more
europepmc   +1 more source

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

iMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I. Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang, Kewei Fan, Xiaole Yin, Hein Min Tun, Renyou Gan, Haichong Wu, Qi Su   +15 more
wiley   +1 more source

The Open Reading Frame 7b of the SARS-CoV-2 Disperse Trans-Golgi and Activate the NLRP3 Inflammasome. [PDF]

J Med Virol
García-Villalba J, Hurtado-Navarro L, Angosto-Bazarra D, Baroja-Mazo A, Pelegrin P.   +4 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

The NLRP3 Inflammasome in Neuropsychiatric Disorders: Molecular Mechanisms and Emerging Therapeutic Strategies. [PDF]

Int J Mol Sci
Neamțu M, Petreuș T, Olinici DT, Stoica L, Arcan OD, Stoica BA, Moșoiu C.   +6 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells. [PDF]

EMBO J
Tesfamariam YM, Christensen MH, Diehl S, Klein T, Lingnau JM, Normann S, Hagelauer E, Herbert M, Reimer S, Joshi RP, Engels P, Pritzl S, Fontana P, Zillinger T, Hartmann G, Eis-Hübinger A, Lam MC, Walgenbach KJ, Meissner F, Wu H, Schmidt FI.   +20 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Research advances on NLRP3 inflammasomes in organ transplantation. [PDF]

Front Immunol
Wang K, Luo H, Ma XJ, Zhang Y, Chen YX, Li T, Wang Y, Jiang HT.   +7 more
europepmc   +1 more source