Results 211 to 220 of about 30,720 (259)

The mechanism and therapeutic prospect of HIF-1 α/BNIP3 pathway in regulating mitophagy in tubulointerstitial fibrosis. [PDF]

Ren Fail
Wang X, Guo Z.
europepmc   +1 more source

Nerandomilast and the Evolving Therapeutic Paradigm in Pulmonary Fibrosis: From Mechanism to Clinical Efficacy

iNew Medicine, EarlyView.
Therapeutic mechanism, clinical efficacy and future directions for nerandomilast in pulmonary fibrosis. ABSTRACT The recent Phase III FIBRONEER trials establish nerandomilast, a novel oral phosphodiesterase 4B (PDE4B) inhibitor, as an effective therapy for idiopathic and progressive pulmonary fibrosis. By elevating cyclic adenosine monophosphate (cAMP),
Qianwen Bai, Jia Deng, Hongquan Wang, Yao Yao, Tao Wang   +4 more
wiley   +1 more source

Correction: Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study. [PDF]

PLoS One
Thahiem S, Ihsan M, Muneer H, Sohail A, Khan M, Murtaza I, Uddin Z, Shafique M, Alzahrani KJ, Ali H, Ullah I.   +10 more
europepmc   +1 more source

TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley   +1 more source

Caspase Recruitment Domain Family Member 8: A Favorable Target in the Pathogenesis of Atherosclerosis. [PDF]

Rev Cardiovasc Med
Tian D, Liu L, Zeng GG, He J, Liu H, Ma D, Yang Z, Ma X, Cao Y, Xu C.   +9 more
europepmc   +1 more source

Role of reactive oxygen species and oxidative stress in the pathomechanism of glaucoma. [PDF]

Med Hypothesis Discov Innov Ophthalmol
Chan NTH, Pattamatta U, White A.
europepmc   +1 more source

Mechanistic insights and challenges in mitochondrial regulation of macrophage polarization and inflammatory responses. [PDF]

Front Physiol
Liu X, Liu R.
europepmc   +1 more source

Evaluation of ASC as a therapeutic target for Alzheimer's disease. [PDF]

Alzheimers Dement
Clayton WB, Kulas JA, Liu J, Walia N, Rangel-Barajas C, Johnson T, Zhang J, Huang K, Mesecar AD, Dage JL, Lamb BT, Palkowitz AD, Richardson TI.   +12 more
europepmc   +1 more source

NLR inflammasome pathways: key targets for pathogenesis and therapy of metabolic diseases. [PDF]

Front Immunol
Zhou J, Yang R, Zhu W, He Z, Ma Y, Feng Z, Yu L.   +6 more
europepmc   +1 more source