Results 71 to 80 of about 56,139 (234)

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

EMBO Molecular Medicine, 2022
Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin   +16 more
doaj   +1 more source

Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke

Frontiers in Pharmacology, 2022
Taohong siwu decoction (THSWD) has been shown to have a therapeutic effect on ischemic strokes (IS). However, it is not clear to us whether THSWD reduces deoxyribonucleic acid (DNA) damage after stroke and reduces the inflammatory response caused by the ...
Ni Wang, Ni Wang, Ni Wang, Ni Wang, Ni Wang, Furui Chu, Furui Chu, Furui Chu, Furui Chu, Furui Chu, Lijuan Zhang, Lijuan Zhang, Changyi Fei, Changyi Fei, Chao Yu, Chao Yu, Sujun Xue, Sujun Xue, Yongzhong Wang, Ling Fang, Daiyin Peng, Daiyin Peng, Daiyin Peng, Xianchun Duan, Xianchun Duan, Xianchun Duan, Xianchun Duan, Xianchun Duan, Weidong Chen, Weidong Chen, Weidong Chen   +30 more
doaj   +1 more source

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources

Atheroma and the inflammasome [PDF]

Journal of Nuclear Cardiology, 2015
Atherosclerosis is a ubiquitous disorder that begins in childhood. An autopsy study of 2,876 adolescents and young adults (ages 15-34) who died of external causes found fatty streaks in the aorta of 100% of subjects, and in the right coronary artery in half the subjects. The number and extent of lesions increased with age.
openaire   +3 more sources

Inflammasomes in Tissue Damages and Immune Disorders After Trauma

Frontiers in Immunology, 2018
Trauma remains a leading cause of death worldwide. Hemorrhagic shock and direct injury to vital organs are responsible for early mortality whereas most delayed deaths are secondary to complex pathophysiological processes.
Perrine Bortolotti, Emmanuel Faure, Eric Kipnis, Eric Kipnis   +3 more
doaj   +1 more source

Predicting COVID-19 distribution in Mexico through a discrete and time-dependent Markov chain and an SIR-like model [PDF]

arXiv, 2020
COVID-19 is an emergent viral infection which rose in December 2019 in a city in the Chinese province of Hubei, Wuhan; the viral aetiology of this infection is now known as COVID-19 virus, which belongs to the Betacoronavirus genus. This virus produces the syndrome of acute respiratory stress that h as been witnessed in other coronaviruses, such as ...
arxiv  

The interaction of inflammasomes and gut microbiota: novel therapeutic insights

Cell Communication and Signaling
Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs).
Shirin Manshouri, Farhad Seif, Monireh Kamali, Mohammad Ali Bahar, Arshideh Mashayekh, Rasol Molatefi   +5 more
doaj   +1 more source

Pyroptosis: a new insight into intestinal inflammation and cancer

Frontiers in Immunology
Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy.
Limin Chao, Wenjing Zhang, Yuchao Feng, Pei Gao, Jinyou Ma   +4 more
doaj   +1 more source

One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]

, 2015
Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA, DE SANTIS, Elena, Limana, F, Perrone, Ga, POLLETTA, LUCIA, RUNCI, ALESSANDRA, RUSSO, Matteo Antonio, SANSONE, LUIGI, TAFANI, MARCO   +8 more
core   +1 more source

Zebrafish in Inflammasome Research [PDF]

Cells, 2019
Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge.
Gabriel Forn-Cuní, Annemarie H. Meijer, Monica Varela   +2 more
openaire   +5 more sources