Results 71 to 80 of about 47,495 (266)

Inflammasomes in neurodegenerative diseases

Translational Neurodegeneration
Inflammasomes represent a crucial component of the innate immune system, which respond to threats by recognizing different molecules. These are known as pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns ...
Qianchen Wang, Songwei Yang, Xuan Zhang, Shanshan Zhang, Liping Chen, Wanxue Wang, Naihong Chen, Jiaqing Yan   +7 more
doaj   +1 more source

The Role of AIM2 Inflammasome in Knee Osteoarthritis

Journal of Inflammation Research, 2022
Jiyong Yang,1 Wengang Liu2 1The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510095, People’s Republic of China; 2Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou, 510095, People’s Republic of ...
Yang J, Liu W
doaj  

Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin [PDF]

, 2012
Heather W. Stout-Delgado, Sarah Vaughan, Anushree C. Shirali, Richard J. Jaramillo, Kevin S. Harrod   +4 more
openalex   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Inflammasomes: potential therapeutic targets in hematopoietic stem cell transplantation

Cell Communication and Signaling
The realm of hematopoietic stem cell transplantation (HSCT) has witnessed remarkable advancements in elevating the cure and survival rates for patients with both malignant and non-malignant hematologic diseases.
Jieya Luo, Yunxia Zhou, Mingyang Wang, Junan Zhang, Erlie Jiang   +4 more
doaj   +1 more source

From inflammatory signaling to neuronal damage: Exploring NLR inflammasomes in ageing neurological disorders

Heliyon
The persistence of neuronal degeneration and damage is a major obstacle in ageing medicine. Nucleotide-binding oligomerization domain (NOD)-like receptors detect environmental stressors and trigger the maturation and secretion of pro-inflammatory ...
Jingwen Zhang, Dong Xie, Danli Jiao, Shuang Zhou, Shimin Liu, Ziyong Ju, Li Hu, Li Qi, Chongjie Yao, Chen Zhao   +9 more
doaj   +1 more source

Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish

, 2022
Sylwia D. Tyrkalska, Annamaria Pedoto, Alicia Martínez‐López, José Antonio Ros, Pablo Mesa-del-Castillo, Sergio Candel, Víctoriano Mulero   +6 more
openalex   +2 more sources

Placentas from Women with Late-Onset Preeclampsia Exhibit Increased Expression of the NLRP3 Inflammasome Machinery [PDF]

, 2023
Luis M. García-Puente, Óscar Fraile-Martínez, Cielo García‐Montero, Julia Buján, Juan A. De León-Luis, Coral Bravo, Patrocinio Rodríguez Benítez, Pilar Pintado, Javier Ruiz-Labarta, Melchor Álvarez‐Mon, Natalio Garcı́a-Honduvilla, María Jesús Cancelo Hidalgo, Miguel A. Sáez, Miguel Á. Ortega   +13 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Peripheral-Central Neuroimmune Crosstalk in Parkinson's Disease: What Do Patients and Animal Models Tell Us?

Frontiers in Neurology, 2019
The brain is no longer considered an immune privileged organ and neuroinflammation has long been associated with Parkinson's disease. Accumulating evidence demonstrates that innate and adaptive responses take place in the CNS.
Marie Therese Fuzzati-Armentero, Silvia Cerri, Fabio Blandini   +2 more
doaj   +1 more source