Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century. [PDF]
, 2016 Air pollution is a severe threat to public health globally, affecting everyone in developed and developing countries alike. Among different air pollutants, particulate matter (PM), particularly combustion-produced fine PM (PM2.5) has been shown to play a
Liu, Sijin +4 more
core +2 more sources
Inflammasomes and their role in innate immunity of Sexually Transmitted Infections
Frontiers in Immunology, 2016 Inflammasomes are multiprotein complexes present in the cytosol as Pattern Recognition Receptors (PRRs) or as sensors of Damage Associated Molecular Patterns (DAMPs).
Vivek Verma +3 more
doaj +1 more source
Pseudomonas aeruginosa pilin activates the inflammasome [PDF]
, 2011 IL-1 beta is produced from inactive pro-IL-1 beta by activation of caspase-1 brought about by a multi-subunit protein platform called the inflammasome. Many bacteria can trigger inflammasome activity through flagellin activation of the host protein NLRC4.
Agostini +54 more
core +1 more source
Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review
Mediators of Inflammation, 2018 Inflammasomes are multiprotein complexes that can sense pathogen-associated molecular patterns and damage-associated molecular signals. They are involved in the initiation and development of inflammation via activation of IL-1β and IL-18.
Yue Lang +6 more
doaj +1 more source
DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]
, 2018 Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping +21 more
core +2 more sources
Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives
Journal of Functional BiomaterialsThis review aimed at searching literature for data regarding the inflammasomes’ involvement in the pathogenesis of oral diseases (mainly periodontitis) and general pathologies, including approaches to control inflammasome-related pathogenic mechanisms ...
Norina Vinţeler +7 more
doaj +1 more source
Acta Dermato-Venereologica, 2022 NLRP3 inflammasome is suggested to contribute to the complex pathogenesis of systemic lupus erythematosus, but its role in cutaneous lupus erythematosus has not been addressed.
Katariina Mähönen +6 more
doaj +1 more source
Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes. [PDF]
, 2017 Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with ...
Eder, C, Scholz, H
core +1 more source
The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney [PDF]
Cells, 2019 Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) forms an inflammasome with apoptosis-associated speck-like protein containing a CARD (ASC) and pro-caspase-1, which is followed by the cleavage of pro-caspase-1 to active caspase-1 and ultimately the activation of IL-1β and IL-18 and induction of pyroptosis in immune ...
Kipyo Kim +4 more
openaire +4 more sources
Diverse Control Mechanisms of the Interleukin-1 Cytokine Family
Frontiers in Cell and Developmental Biology, 2022 The majority of interleukin-1 (IL-1) family cytokines lack amino terminal secretion signals or transmembrane domains for secretion along the conventional biosynthetic pathway.
Charles L. Evavold, Jonathan C. Kagan
doaj +1 more source