Results 51 to 60 of about 3,006,442 (287)

Lipid Mediators in the Resolution of Inflammation [PDF]

Cold Spring Harbor Perspectives in Biology, 2014
Mounting of the acute inflammatory response is crucial for host defense and pivotal to the development of chronic inflammation, fibrosis, or abscess formation versus the protective response and the need of the host tissues to return to homeostasis. Within self-limited acute inflammatory exudates, novel families of lipid mediators are identified, named ...
Charles N, Serhan, Nan, Chiang, Jesmond, Dalli, Bruce D, Levy   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Resolution of Inflammation: What Controls its Onset? [PDF]

, 2016
An effective resolution program may be able to prevent the progression from non-resolving acute inflammation to persistent chronic inflammation. It has now become evident that coordinated resolution programs initiate shortly after inflammatory responses ...
Mauro Perretti, Lirlândia Pires de Sousa, Vanessa ePinho, Lirlândia P. Sousa, Pinho, V, Sousa, LP, Perretti, M, Michelle Amantéa Sugimoto, Michelle A. Sugimoto, Lirlândia Pires Sousa, Mauro ePerretti, Teixeira, MM, Mauro M. Teixeira, Sugimoto, MA, Michelle Adriane Amantéa Sugimoto, Vanessa Pinho, Mauro Martins Teixeira   +16 more
core   +1 more source

Resolution of inflammation during rheumatoid arthritis

Frontiers in Cell and Developmental Biology
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes synovial joint inflammation as well as bone destruction and erosion, typically characterized by joint pain, swelling, and stiffness, with complications and persistent pain after ...
Xiaoou Ye, Dan Ren, Qingyuan Chen, Jiquan Shen, Jiquan Shen, Bo Wang, Bo Wang, Songquan Wu, Hongliang Zhang   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effects of resveratrol in ınflammatory arthritis

, 2007
Inflammation, Vol. 30, Nos. 1Y2, April 2007 ( 2006)Summary: Nuclear factor kappa B (NF-kB), is a pivotal transcription factor involved in the activation of the TNF-a and IL-1b genes.
Baysal, Özlem, Esenkaya, İrfan, Mızrak, Bülent, Elmalı, Nurzat, Harma, Ahmet   +4 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Resolution of inflammation in inflammatory bowel disease [PDF]

, 2017
Treatment of inflammatory bowel disease at present mainly targets mediators of inflammation to stop or suppress pro-inflammatory processes. Typical examples are steroids, suppression of T cells by thioguanine nucleotides, or antibodies against cytokines ...
Rogler, Gerhard, Gerhard Rogler
core   +1 more source

Utilization of lipoxins and other specialised pro-resolving mediators in the prevention and treatment of diabetic nephropathy and diabetic cardiovascular disease

Acta Marisiensis - Seria Medica
Diabetes mellitus type 2 is a chronic disease caused by insulin resistance. Whilst first originating in the adipose tissue, this pathophysiological process later affects the muscles and the liver as well.
Bergo Ivan, Pastorello Ylenia
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source