Results 71 to 80 of about 3,006,442 (287)
Pifu-xingbing zhenliaoxue zazhi[Objective] To elucidate the anti-inflammatory effects and underlying molecular mechanisms of recombinant ANKRD22 protein in dendritic cells, and to assess its therapeutic efficacy in mitigating the progression of psoriasis.
LIANG Kaiyu, JI Suyun, XIA Xichun
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Frontiers in ImmunologyThe concept of “trained immunity,” which refers to a type of long-term immunological memory within innate cells, has significantly challenged the traditional division between the non-specific innate and antigen-specific adaptive immune systems ...
Yahui Li, Dongdong Wang
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Frontiers in ImmunologyChronic obstructive pulmonary disease (COPD) is driven by self-perpetuating inflammation that resists conventional therapies. Recent evidence reveals three interconnected pathogenic layers: immunometabolic reprogramming, m6A epitranscriptomic ...
Hui-Hui Chen +6 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Frontiers in Cardiovascular MedicineBackgroundSystemic inflammatory response is an important biological factor that determines morbidity after cardiac interventions. Minimally invasive cardiac surgery (MICS) was conceived to reduce surgical trauma but the subtle dynamics of its effect on ...
Chang Wang +10 more
doaj +1 more source
Медицинский совет, 2020 Sports injuries of the musculoskeletal system of different localization represent actual problems of modern traumatology and rehabilitation. Despite the large number of proposed methods of therapy, the question of the management of injuries in athletes ...
D. M. Lurie
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in ImmunologyInflammatory disease is sustained not only by immune activation but also by the failure of activated cells to terminate effector programs and return tissues to homeostasis.
Yizhang Zhu +4 more
doaj +1 more source