Results 221 to 230 of about 17,106 (263)

Sterol Biosynthesis Inhibitors

Annals of the New York Academy of Sciences, 1988
Sterol biosynthesis inhibitors such as the imidazoles and 1,2,4-triazoles are generally regarded as inhibitors of sterol C-14 demethylation. Neither the MIC values nor the data for direct interaction with the cytochrome P-450 responsible for oxidative C-14 methyl removal, however, fully explain the observed in vivo efficacy.
D, Berg, M, Plempel, K H, Büchel, G, Holmwood, K, Stroech   +4 more
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Antimycotic sterol biosynthesis inhibitors

Trends in Pharmacological Sciences, 1986
Abstract The last decade or so has seen the development and increased use of the antifungal azoles. D. Berg and colleagues describe the pharmacology and medicinal chemistry of these compounds which has allowed research in this field to move towards the development of analogues with reduced toxicity suitable for oral and parenteral administration.
D. Berg, K.-H. Büchel, M. Plempel, E. Regel   +3 more
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An Inhibitor of Sterol Biosynthesis present in Cow's Milk

Nature, 1974
RECENT evidence indicates that sterol biosynthesis from acetate, but not from mevalonate, increases several-fold in the developing rat liver after weaning1. This increase parallels the postnatal rise in activity of liver 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), an enzyme which seems to catalyse the rate-limiting key reaction of ...
W, Boguslawski, J, Wröbel
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Inhibitors of sterol biosynthesis. Synthesis and activities of ring C oxygenated sterols

Chemistry and Physics of Lipids, 1988
The chemical syntheses of a number of C27 ring C oxygenated sterols have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in cultured mammalian cells. Thus, 5 alpha-cholest-7-ene-3 beta, 11 alpha-diol, 3 alpha-hydroxy-5 alpha-cholest-9(11)-en-12-one, and the previously unreported 11 alpha-hydroxy-5 alpha ...
Schroepfer, G J, Parish, E J, Kandutsch, A A   +2 more
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Antifungal Sterol Biosynthesis Inhibitors

1997
During the course of the last decade, the development of SBIs, and particularly sterol biomethylation inhibitors, has been based on the rational design approach. Successful though this approach has been in elucidating sterol biomethylation enzymology, its limitations are becoming apparent from the findings that: (i) 24,25-double bond metabolism gives ...
D A, Guo, A T, Mangla, W, Zhou, M, Lopez, Z, Jia, S D, Nichols, W D, Nes   +6 more
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Steroidal allenes as inhibitors of sterol biosynthesis

Journal of the Chemical Society, Chemical Communications, 1975
Allenic analogues (1) and (2) of fucosterol (9) and desmosterol (11) were synthesized and the former was found to be a specific inhibitor of sterol metabolism in the silkworm.
M. Morisaki, N. Awata, Y. Fujimoto, N. Ikekawa   +3 more
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Effects of sterol biosynthesis inhibitors on mitosis

Pesticide Biochemistry and Physiology, 1990
Abstract The sterol biosynthesis inhibitors (SBIs) fenarimol, triadimenol, bitertanol, miconazole, clotrimazole, and fenpropimorph increase sectoring in a heterozygous diploid strain of Aspergillus nidulans , but only at concentrations highly inhibitory to growth. Analysis of color segregants suggest that SBIs cause chromosome nondisjunction.
B.N. Ziogas, A.G. Vitoratos, E.G. Sideris, S.G. Georgopoulos   +3 more
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Syntheses of Ring C Oxysterols: Inhibitors of Sterol Biosynthesis

Lipids, 2007
AbstractOxygenated derivates of cholesterol and lanosterol, known as oxysterols, have consistently displayed significant activity as inhibitors of 3‐hydroxy‐3‐methylglutaryl (HMG) CoA reductase, a key regulatory enzyme in sterol biosynthesis. We have developed the chemical syntheses of ring C oxysterols for evaluation as inhibitors of sterol ...
Edward J, Parish, Chi, Luo, Thomas, Webb, John D, Gorden   +3 more
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A reporter gene assay for fungal sterol biosynthesis inhibitors

The Journal of Steroid Biochemistry and Molecular Biology, 1997
Acetoacetyl-CoA thiolase (ACoAT) catalyses the condensation of two acetyl-CoA molecules, the first step in the sterol biosynthetic pathway. We constructed a yeast strain containing a fusion of the promoter of the Saccharomyces cerevisiae ACoAT gene to a reporter gene (Escherichia coli beta-galactosidase).
G, Dixon, D, Scanlon, S, Cooper, P, Broad   +3 more
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Rationally Designed Inhibitors of Sterol Biosynthesis

1992
Sterols play vital hormonal, regulatory, and architectural roles in all living organisms. As knowledge of their biosynthetic pathways has grown, so has the possibility for manipulation. One of the most exciting and promising strategies to develop over the past 15 years has been the interference of specific sterol biosynthetic enzymes by mechanism-based
A. C. Oehlschlager, Eva Czyzewska
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