Results 221 to 230 of about 32,395 (260)
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Rationally Designed Inhibitors of Sterol Biosynthesis
1992Sterols play vital hormonal, regulatory, and architectural roles in all living organisms. As knowledge of their biosynthetic pathways has grown, so has the possibility for manipulation. One of the most exciting and promising strategies to develop over the past 15 years has been the interference of specific sterol biosynthetic enzymes by mechanism-based
A. C. Oehlschlager, Eva Czyzewska
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Molecular and Biochemical Parasitology, 2005
Infection with the protozoan, Trypanosoma cruzi, is the cause of Chagas disease that occurs widely throughout Latin America. T. cruzi contains sterol biosynthesis enzymes, and produces sterol products similar to those found in fungi. Antifungal drugs that inhibit ergosterol biosynthesis have potent anti-T.
Eleanor G, Hankins +3 more
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Infection with the protozoan, Trypanosoma cruzi, is the cause of Chagas disease that occurs widely throughout Latin America. T. cruzi contains sterol biosynthesis enzymes, and produces sterol products similar to those found in fungi. Antifungal drugs that inhibit ergosterol biosynthesis have potent anti-T.
Eleanor G, Hankins +3 more
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New Cases of Negative Cross-resistance between Fungicides, Including Sterol Biosynthesis Inhibitors
Journal of General Plant Pathology, 2000A survey of fungicide resistance in Mycosphaerella graminicola and Tapesia acuformis, two major pathogens of winter wheat in France, respectively responsible for speckled leaf blotch and eyespot, led to the characterization of two types of resistant strains to sterol 14α-demethylation inhibitors (DMIs). Most of the strains of M.
Leroux, Pierre +3 more
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Sterol biosynthesis inhibitors: Their current status and modes of action
Lipids, 1991AbstractThe mechanism of each of the reactions in the post‐squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.
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Mycorrhiza, 2011
The vegetative compatibility of the arbuscular mycorrhizal fungus (AMF) Glomus clarum MUCL 46238 was evaluated after continuous exposure to fenhexamid, a sterol biosynthesis inhibitor (SBI). Three lineages of this AMF were cultured in vitro for five generations in association with Ri T-DNA transformed carrot roots in the presence of 0, 5 or 10 mg l(-1)
Antonio, Cardenas-Flores +5 more
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The vegetative compatibility of the arbuscular mycorrhizal fungus (AMF) Glomus clarum MUCL 46238 was evaluated after continuous exposure to fenhexamid, a sterol biosynthesis inhibitor (SBI). Three lineages of this AMF were cultured in vitro for five generations in association with Ri T-DNA transformed carrot roots in the presence of 0, 5 or 10 mg l(-1)
Antonio, Cardenas-Flores +5 more
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Effect of inhibitors of sterol biosynthesis on growth and sexuality of pythium and zygorhynchus
Mycopathologia, 1976Seven commercial inhibitors of sterol biosynthesis were tested for their effect upon vegatative growth and sexuality in Pythium acanthicum and Zygorhynchus moelleri. Five compounds (SKF 525, Chlorpropamide, Tolbutamide, Benzmalacene, AY 9944) inhibited both growth and sexuality of both fungi and two (SKF 7732 and SKF 7997) were ineffective. Pythium was
J J, Child, R H, Haskins
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Mechanism of action of Denmert, an inhibitor of sterol biosynthesis
Netherlands Journal of Plant Pathology, 1977Effects of the fungicide Denmert on sterol biosynthesis were examined. The rates of inhibition of ergosterol formation were roughly correlated to its fungitoxic activity among four fungal species tested. In cell-free homogenates of yeast (S. cerevisiae), the fungicide blocked the conversion of lanosterol to 14-desmethyl-lanosterol.
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Effect of different inhibitors of sterol biosynthesis on both fungal growth and aflatoxin production
Natural Toxins, 1995AbstractAzole antifungals are reported to interfere with fungal growth by selective impairment of the P‐450 dependent 14 a‐demethylase system key to biosynthesis of ergosterol (ERG), thus leading to the depletion of this sterol in fungal membranes and to the accumulation of methylated precursors.We have investigated whether azole antifungals ...
FANELLI, Corrado +4 more
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7-Oxo-24ξ(28)-dihydrocycloeucalenol, a potent inhibitor of plant sterol biosynthesis
Phytochemistry, 1982Abstract Cycloeucalenol-obtusifoliol isomerase from higher plant cells catalyses the opening of the cyclopropane ring of cycloeucalenol yielding obtusifoliol. 7-Oxo-24ξ(28)-dihydrocycloeucalenol was not a substrate but behaved like a potent inhibitor of the isomerase.
Alain Rahier +2 more
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Steroids, 1993
The inhibitory effect of SSF-109 on cholesterol synthesis in isolated hepatocytes was studied using a radio-high-performance liquid chromatography system, and the results were compared with those of other inhibitors, triparanol and AMO-1618. SSF-109 caused accumulation of two trimethylsterols: lanosterol and 24-dihydrolanosterol.
S, Seo +4 more
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The inhibitory effect of SSF-109 on cholesterol synthesis in isolated hepatocytes was studied using a radio-high-performance liquid chromatography system, and the results were compared with those of other inhibitors, triparanol and AMO-1618. SSF-109 caused accumulation of two trimethylsterols: lanosterol and 24-dihydrolanosterol.
S, Seo +4 more
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