Results 211 to 220 of about 32,395 (260)

Sterol-C4-methyl-oxidase Erg251 governs Candida albicans hypoxic growth, commensalism and virulence. [PDF]

Nat Commun
Liu Z, Yiu B, Basso P, Chen X, Patel D, Davie T, Hossain S, Fu C, Archambault LS, Duncan D, Wright GD, Noble SM, Robbins N, Cowen LE.   +13 more
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Inhibitors of sterol biosynthesis and growth in plants and fungi

Phytochemistry, 1989
Abstract Sterols and their derivatives promote and maintain growth and development in plants and fungi by acting as membrane constituents and probably also as hormones, engaged in control of metabolism. Inhibitors of sterol biosynthesis, operating at various stages in the pathway, are useful probes for investigating these functions.
Raymond S. Burden, David T. Cooke, Geoffrey A. Carter   +2 more
exaly   +4 more sources

Use of rationally designed inhibitors to study sterol and triterpenoid biosynthesis

Pure and Applied Chemistry, 1987
Abstract
M. Taton, P. Benveniste, A. Rahier
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Inhibitors of sterol biosynthesis and their applications

Progress in Lipid Research, 1993
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Inhibitors of sterol biosynthesis. Synthesis and activities of ring C oxygenated sterols

Chemistry and Physics of Lipids, 1988
The chemical syntheses of a number of C27 ring C oxygenated sterols have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in cultured mammalian cells. Thus, 5 alpha-cholest-7-ene-3 beta, 11 alpha-diol, 3 alpha-hydroxy-5 alpha-cholest-9(11)-en-12-one, and the previously unreported 11 alpha-hydroxy-5 alpha ...
Schroepfer, G J, Parish, E J, Kandutsch, A A   +2 more
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Syntheses of Ring C Oxysterols: Inhibitors of Sterol Biosynthesis

Lipids, 2007
AbstractOxygenated derivates of cholesterol and lanosterol, known as oxysterols, have consistently displayed significant activity as inhibitors of 3‐hydroxy‐3‐methylglutaryl (HMG) CoA reductase, a key regulatory enzyme in sterol biosynthesis. We have developed the chemical syntheses of ring C oxysterols for evaluation as inhibitors of sterol ...
Edward J, Parish, Chi, Luo, Thomas, Webb, John D, Gorden   +3 more
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Steroidal allenes as inhibitors of sterol biosynthesis

Journal of the Chemical Society, Chemical Communications, 1975
Allenic analogues (1) and (2) of fucosterol (9) and desmosterol (11) were synthesized and the former was found to be a specific inhibitor of sterol metabolism in the silkworm.
M. Morisaki, N. Awata, Y. Fujimoto, N. Ikekawa   +3 more
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Effects of sterol biosynthesis inhibitors on mitosis

Pesticide Biochemistry and Physiology, 1990
Abstract The sterol biosynthesis inhibitors (SBIs) fenarimol, triadimenol, bitertanol, miconazole, clotrimazole, and fenpropimorph increase sectoring in a heterozygous diploid strain of Aspergillus nidulans , but only at concentrations highly inhibitory to growth. Analysis of color segregants suggest that SBIs cause chromosome nondisjunction.
B.N. Ziogas, A.G. Vitoratos, E.G. Sideris, S.G. Georgopoulos   +3 more
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An Inhibitor of Sterol Biosynthesis present in Cow's Milk

Nature, 1974
RECENT evidence indicates that sterol biosynthesis from acetate, but not from mevalonate, increases several-fold in the developing rat liver after weaning1. This increase parallels the postnatal rise in activity of liver 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), an enzyme which seems to catalyse the rate-limiting key reaction of ...
W, Boguslawski, J, Wröbel
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Inhibitors of sterol biosynthesis. Syntheses of 14α-alkyl substituted 15-oxygenated sterols

Chemistry and Physics of Lipids, 1979
Abstract The chemical syntheses of a number of 14α-alkyl substituted 15-oxygenated sterols have been pursued to permit evaluation of their activity in the inhibition of the biosynthesis of cholesterol and other biological effects. Described herein are the first chemical syntheses of 14α-ethyl-5α-cholest-7-en-3β-ol-15-one, bis-3β,15α-acetoxy-14α-ethyl-
Edward J. Parish, Mitsuhiro Tsuda, George J. Schroepfer   +2 more
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