Results 191 to 200 of about 16,603 (230)
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Inhibitors of sterol biosynthesis. Synthesis and activities of ring C oxygenated sterols
Chemistry and Physics of Lipids, 1988The chemical syntheses of a number of C27 ring C oxygenated sterols have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in cultured mammalian cells. Thus, 5 alpha-cholest-7-ene-3 beta, 11 alpha-diol, 3 alpha-hydroxy-5 alpha-cholest-9(11)-en-12-one, and the previously unreported 11 alpha-hydroxy-5 alpha ...
Schroepfer, G J +2 more
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Antifungal Sterol Biosynthesis Inhibitors
1997During the course of the last decade, the development of SBIs, and particularly sterol biomethylation inhibitors, has been based on the rational design approach. Successful though this approach has been in elucidating sterol biomethylation enzymology, its limitations are becoming apparent from the findings that: (i) 24,25-double bond metabolism gives ...
D A, Guo +6 more
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Steroidal allenes as inhibitors of sterol biosynthesis
Journal of the Chemical Society, Chemical Communications, 1975Allenic analogues (1) and (2) of fucosterol (9) and desmosterol (11) were synthesized and the former was found to be a specific inhibitor of sterol metabolism in the silkworm.
M. Morisaki +3 more
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Effects of sterol biosynthesis inhibitors on mitosis
Pesticide Biochemistry and Physiology, 1990Abstract The sterol biosynthesis inhibitors (SBIs) fenarimol, triadimenol, bitertanol, miconazole, clotrimazole, and fenpropimorph increase sectoring in a heterozygous diploid strain of Aspergillus nidulans , but only at concentrations highly inhibitory to growth. Analysis of color segregants suggest that SBIs cause chromosome nondisjunction.
B.N. Ziogas +3 more
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Syntheses of Ring C Oxysterols: Inhibitors of Sterol Biosynthesis
Lipids, 2007AbstractOxygenated derivates of cholesterol and lanosterol, known as oxysterols, have consistently displayed significant activity as inhibitors of 3‐hydroxy‐3‐methylglutaryl (HMG) CoA reductase, a key regulatory enzyme in sterol biosynthesis. We have developed the chemical syntheses of ring C oxysterols for evaluation as inhibitors of sterol ...
Edward J, Parish +3 more
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Rationally Designed Inhibitors of Sterol Biosynthesis
1992Sterols play vital hormonal, regulatory, and architectural roles in all living organisms. As knowledge of their biosynthetic pathways has grown, so has the possibility for manipulation. One of the most exciting and promising strategies to develop over the past 15 years has been the interference of specific sterol biosynthetic enzymes by mechanism-based
A. C. Oehlschlager, Eva Czyzewska
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A reporter gene assay for fungal sterol biosynthesis inhibitors
The Journal of Steroid Biochemistry and Molecular Biology, 1997Acetoacetyl-CoA thiolase (ACoAT) catalyses the condensation of two acetyl-CoA molecules, the first step in the sterol biosynthetic pathway. We constructed a yeast strain containing a fusion of the promoter of the Saccharomyces cerevisiae ACoAT gene to a reporter gene (Escherichia coli beta-galactosidase).
G, Dixon +3 more
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Understanding resistance to sterol biosynthesis inhibitor fungicides
2023This chapter discusses understanding resistance to sterol biosynthesis inhibitor (SBI) fungicides. It starts by first highlighting the current market and trends for this type of fungicide, then goes on to provide a short history of de-methylation inhibitor (DMI) fungicides, one of the four subclasses SBI fungicides can be divided into.
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Sterol biosynthesis inhibitors: Their current status and modes of action
Lipids, 1991AbstractThe mechanism of each of the reactions in the post‐squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.
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General resistance to sterol biosynthesis inhibitors inSaccharomyces cerevisiae
Lipids, 1993AbstractScreening for resistance to fenpropimorph was undertaken in order to isolate yeast mutants affected in the regulation of the ergosterol pathway. Among the mutants isolated, one bearing the recessivefen1‐1 mutation was characterized by a 1.5‐fold increase in the ergosterol level and a general resistance to sterol biosynthesis inhibitors. Thefen1‐
V, Ladevèze +3 more
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