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De Novo Lipogenesis in Clear Cell Renal Cell Carcinoma: Mechanistic Insights and Therapeutic Implications. [PDF]
Int J Mol SciBui KCL, Do YT, Kim JY, Seo JH.
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Inhibitors of sterol biosynthesis and growth in plants and fungi
Phytochemistry, 1989Abstract Sterols and their derivatives promote and maintain growth and development in plants and fungi by acting as membrane constituents and probably also as hormones, engaged in control of metabolism. Inhibitors of sterol biosynthesis, operating at various stages in the pathway, are useful probes for investigating these functions.
David T Cooke
exaly +2 more sources
Molecular and Biochemical Parasitology, 2005
Infection with the protozoan, Trypanosoma cruzi, is the cause of Chagas disease that occurs widely throughout Latin America. T. cruzi contains sterol biosynthesis enzymes, and produces sterol products similar to those found in fungi. Antifungal drugs that inhibit ergosterol biosynthesis have potent anti-T.
Frederick Buckner
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Infection with the protozoan, Trypanosoma cruzi, is the cause of Chagas disease that occurs widely throughout Latin America. T. cruzi contains sterol biosynthesis enzymes, and produces sterol products similar to those found in fungi. Antifungal drugs that inhibit ergosterol biosynthesis have potent anti-T.
Frederick Buckner
exaly +3 more sources
Effect of inhibitors of sterol biosynthesis on growth and sexuality of pythium and zygorhynchus
Mycopathologia, 1976Seven commercial inhibitors of sterol biosynthesis were tested for their effect upon vegatative growth and sexuality in Pythium acanthicum and Zygorhynchus moelleri. Five compounds (SKF 525, Chlorpropamide, Tolbutamide, Benzmalacene, AY 9944) inhibited both growth and sexuality of both fungi and two (SKF 7732 and SKF 7997) were ineffective. Pythium was
R H Haskins
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Bioorganic and Medicinal Chemistry, 2009
The synthesis of some novel azasteroids and thiasteroids based on a pregnan nucleus with a Delta7 double bond in two to five steps from the key aldehyde (3S,20S)-20-formylpregn-7-en-3-yl acetate has been disclosed herein. These compounds were evaluated as potential inhibitors of the enzyme Delta24-sterol methyltransferase (24-SMT), which is a key ...
Franz Bracher, Martin Giera
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The synthesis of some novel azasteroids and thiasteroids based on a pregnan nucleus with a Delta7 double bond in two to five steps from the key aldehyde (3S,20S)-20-formylpregn-7-en-3-yl acetate has been disclosed herein. These compounds were evaluated as potential inhibitors of the enzyme Delta24-sterol methyltransferase (24-SMT), which is a key ...
Franz Bracher, Martin Giera
exaly +3 more sources
Sterol Biosynthesis Inhibitors: C-4 Demethylation
2015Two available fungicides block sterol C-4 demethylation in ergosterol biosynthesis: the hydroxyanilide fenhexamid and the amino-pyrazolinone fenpyrazamine, introduced in the early 2000s and 2010s, respectively. Both these fungicides specifically target 3-ketoreductase (Erg27), the third enzyme of the C-4 demethylation enzyme complex.
Pierre Leroux
exaly +2 more sources
Inhibitors of sterol biosynthesis and their applications
Progress in Lipid Research, 1993exaly +3 more sources
Sterol Biosynthesis Inhibitors
Annals of the New York Academy of Sciences, 1988Sterol biosynthesis inhibitors such as the imidazoles and 1,2,4-triazoles are generally regarded as inhibitors of sterol C-14 demethylation. Neither the MIC values nor the data for direct interaction with the cytochrome P-450 responsible for oxidative C-14 methyl removal, however, fully explain the observed in vivo efficacy.
D, Berg +4 more
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Antimycotic sterol biosynthesis inhibitors
Trends in Pharmacological Sciences, 1986Abstract The last decade or so has seen the development and increased use of the antifungal azoles. D. Berg and colleagues describe the pharmacology and medicinal chemistry of these compounds which has allowed research in this field to move towards the development of analogues with reduced toxicity suitable for oral and parenteral administration.
D. Berg +3 more
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An Inhibitor of Sterol Biosynthesis present in Cow's Milk
Nature, 1974RECENT evidence indicates that sterol biosynthesis from acetate, but not from mevalonate, increases several-fold in the developing rat liver after weaning1. This increase parallels the postnatal rise in activity of liver 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), an enzyme which seems to catalyse the rate-limiting key reaction of ...
W, Boguslawski, J, Wröbel
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