Results 231 to 240 of about 17,106 (263)
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Sterol biosynthesis inhibitors: Their current status and modes of action
Lipids, 1991AbstractThe mechanism of each of the reactions in the post‐squalene segment of the fungal and higher plant sterol biosynthetic pathway is outlined. The inhibitors of the enzymes catalyzing the reactions are described and how inhibition is brought about is explained in the areas where it is known.
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General resistance to sterol biosynthesis inhibitors inSaccharomyces cerevisiae
Lipids, 1993AbstractScreening for resistance to fenpropimorph was undertaken in order to isolate yeast mutants affected in the regulation of the ergosterol pathway. Among the mutants isolated, one bearing the recessivefen1‐1 mutation was characterized by a 1.5‐fold increase in the ergosterol level and a general resistance to sterol biosynthesis inhibitors. Thefen1‐
V, Ladevèze +3 more
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Sterol Biosynthesis Inhibitors: C14 Demethylation (DMIs)
2015DMIs are a commercially very successful group of systemic fungicides targeting cell membrane integrity by inhibiting C14 demethylation during sterol formation. Regardless of their site-specific mode of action, resistance development evolved in a typical stepwise manner leading to a prolonged effectiveness for more than four decades and rendering those ...
Basil Nicholas Ziogas +1 more
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Understanding resistance to sterol biosynthesis inhibitor fungicides
2023This chapter discusses understanding resistance to sterol biosynthesis inhibitor (SBI) fungicides. It starts by first highlighting the current market and trends for this type of fungicide, then goes on to provide a short history of de-methylation inhibitor (DMI) fungicides, one of the four subclasses SBI fungicides can be divided into.
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Inhibitors of sterol biosynthesis. Syntheses of 14α-alkyl substituted 15-oxygenated sterols
Chemistry and Physics of Lipids, 1979Abstract The chemical syntheses of a number of 14α-alkyl substituted 15-oxygenated sterols have been pursued to permit evaluation of their activity in the inhibition of the biosynthesis of cholesterol and other biological effects. Described herein are the first chemical syntheses of 14α-ethyl-5α-cholest-7-en-3β-ol-15-one, bis-3β,15α-acetoxy-14α-ethyl-
Edward J. Parish +2 more
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Mechanism of action of Denmert, an inhibitor of sterol biosynthesis
Netherlands Journal of Plant Pathology, 1977Effects of the fungicide Denmert on sterol biosynthesis were examined. The rates of inhibition of ergosterol formation were roughly correlated to its fungitoxic activity among four fungal species tested. In cell-free homogenates of yeast (S. cerevisiae), the fungicide blocked the conversion of lanosterol to 14-desmethyl-lanosterol.
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Journal of Atherosclerosis Research, 1964
Summary The concentrations of cholesterol, desmosterol and total sterols (cholesterol plus desmosterol) were determined in the tissues of rats treated with an inhibitor of cholesterol biosynthesis, triparanol. The results were compared with those obtained from non-treated rats (controls).
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Summary The concentrations of cholesterol, desmosterol and total sterols (cholesterol plus desmosterol) were determined in the tissues of rats treated with an inhibitor of cholesterol biosynthesis, triparanol. The results were compared with those obtained from non-treated rats (controls).
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[Micromycetes metabolites--inhibitors of growth and sterol biosynthesis in yeasts].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2002Antifungal activity of micelial fungus metabolites (of genera Aspergillus, Penicillium, Fusarium, Stachybotris, Cladosporium, Alternaria, Gliocladium, Paecilomyces, Trichoderma etc.) was determined. It was shown that antifungal activity of some micromycetes is due to the formation of substances inhibiting sterols biosynthesis in eucaryote cells ...
N A, Baranova +3 more
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