RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. [PDF]
, 2019 Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear ...
Bold, Richard J +21 more
core
Effect of Septoria leaf blotch and its control with commercial fungicides, on arbuscular-mycorrhizal-fungal colonization, spore numbers, and morphotype diversity [PDF]
, 2014 Arbuscular-mycorrhizal internal structures (i.e. total root colonization, arbuscules, vesicles) and external structures (i.e. spore density), and Glomeromycota spore morphotypes, were evaluated in wheat severely infected with Mycosphaerella graminicola –
Cabello, Marta Noemí +3 more
core +1 more source
Species Dependent Toxicity Comparison Outcome
Advanced Science, EarlyView.By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao +7 more
wiley +1 more source
Chitin Synthase, a Fungal Glycosyltransferase that Is a Valuable Antifungal Target
CHIMIA, 2011 During the last 30 past years, more life-threatening fungal infections have appeared due to the increasing frequency of patients with weakened immune systems.
Jean-Bernard Behr
doaj +1 more source
Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
Inhibition of sterol biosynthesis in animal cells by 14 alpha-hydroxymethyl sterols.
Journal of Lipid Research, 1980 The chemical syntheses of a number of 14 alpha-hydroxymethyl sterols and 14 alpha -hydroxymethyl-15 alpha-hydroxysterols and their derivatives have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in animal ...
G J Schroepfer, Jr +3 more
doaj +1 more source
Journal of Lipid Research, 2017 Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24-/28-methylases (SMTs) that ...
Medhanie E. Kidane +7 more
doaj +1 more source
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]
, 2006 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E +6 more
core +1 more source
Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]
, 2020 Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar +10 more
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Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Interdisciplinary Perspectives on Infectious Diseases, 2009 Sterols are constituents of the cellular membranes that are essential for their normal structure and function. In mammalian cells, cholesterol is the main sterol found in the various membranes.
Wanderley de Souza +1 more
doaj +1 more source