Results 71 to 80 of about 17,106 (263)

New cases of negative cross-resistance between fungicides, including sterol biosynthesis inhibitors

, 2000
International audienceA survey of fungicide resistance in Mycosphaerella graminicola and Tapesia acuformis, two major pathogens of winter wheat in France, respectively responsible for speckled leaf blotch and eyespot, led to the characterization of two ...
Leroux, Pierre,, Chapeland, Florence, Arnold, Annick, Leroux, Pierre, P., Gredt, Michel, M., Gredt, Michel,   +5 more
core   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

A schematic representation of various inhibitors that inhibit cholesterol biosynthesis.

, 2013
Cholesterol biosynthesis takes place by two pathways, namely, the Kandutsch-Russell and Bloch pathways. These pathways have common initial steps starting from acetate and branch out after lanosterol.
Amitabha Chattopadhyay (293264), Gopal Pande (32642), Gunda Srinivas (390271), Pushpendra Singh (185150), Roopali Saxena (293259)   +4 more
core   +1 more source

A Link between cholesterol levels and phenobarbital induction of cytochromes P450 [PDF]

, 2002
Squalestatin1 (SQ1), a potent inhibitor of squalene synthase produced a dose-dependent induction of cytochromes P450 CYP2H1 and CYP3A37 mRNAs in chicken hepatoma cells. The effect of SQ1 was completely reversed by 25-hydroxycholesterol.
Christoph Handschin, Handschin, C., Meyer, U. A., Urs A. Meyer, Kaufmann, M., Jean-Claude Ourlin, Michel Kaufmann, Ourlin, J. -C.   +7 more
core   +1 more source

Integrated phytochemical and bioactivity profiling of Xanthium strumarium fruits from Korea and China: Implications for origin‐specific quality specification

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Geographic origin influences the phytochemical composition and biological activities of medicinal plant resources. Xanthium strumarium L. (XS) fruit is widely used in East Asian traditional medicine. However, current pharmacopeial standards primarily recognize Chinese‐derived material, despite the availability and traditional use of
Eunsu Song, Seung‐Min Oh, Jiyeon Chun, Jinah Hwang   +3 more
wiley   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

, 2022
The sterol biosynthesis pathway of Leishmania spp. is used as a pharmacological target; however, available information about the mechanisms of the regulation and remodeling of sterolrelated genes is scarce.
Monte Neto, Rubens Lima do, Fujii, Thais Tenorio Soares, Santos, Eduardo Caio Torres, Guedes, Herbert Leonel de Matos, Gomes, Daniel Claudio de Oliveira, Andrade Neto, Valter Viana, Gomes, Pollyanna Stephanie, Ouellette, Marc   +7 more
core  

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, EarlyView.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

Branched‐Chain Amino and Keto Acids Reduce Hepatocyte Lipid Droplet Size and Number via Distinct Proteomic Pathways

PROTEOMICS, EarlyView.
ABSTRACT Branched‐chain amino acids (BCAA) and their corresponding keto acids (BCKA) have been associated with changes in hepatic lipid metabolism and the resulting alterations in intracellular triglyceride concentrations. In this study, we utilized a previously established hepatocyte model to investigate the impact of BCAA and BCKA supplementation on ...
Jayasimha R. Daddam, Mounica Sura, Edward Kolodziej, Maria Gojcaj, Zheng Zhou   +4 more
wiley   +1 more source