Results 71 to 80 of about 16,603 (230)
Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy
Medicine Advances, EarlyView.Pongamia pinnata phytochemicals have multiple anticancer mechanisms, including antioxidant, anti‐inflammatory, anti‐metastatic, and apoptosis‐inducing activities through molecular‐level regulation. These bioactive compounds protect normal cells from oxidative stress while promoting reactive oxygen species‐mediated tumor cell death and suppressing ...
Rajib Dhar, Vetriselvan Subramaniyan
wiley +1 more source
Marine Drugs, 2017 Sterol 14α-demethylases from Cytochrome P450 family (CYP51s) are essential enzymes in sterol biosynthesis and well-known as the target of antifungal drugs.
Yongze Yuan +8 more
doaj +1 more source
Pest Management Science, EarlyView.We compared two island populations of Bethencourtia palmensis and their culturable endophytic fungi, revealing distinct plant chemistries and a higher biopesticidal potential in the endophytic fungi from La Palma population along with high potential for the discovery of novel compounds.
Jorge Rojas López‐Menchero +4 more
wiley +1 more source
PLoS ONE, 2020 Sterol regulatory element-binding protein (SREBP), a highly conserved family of membrane-bound transcription factors, is an essential regulator for cellular cholesterol and lipid homeostasis in mammalian cells.
Hao Miao +11 more
doaj +1 more source
Chemistry & Biology, 2015 Trypanosoma brucei, the causal agent for sleeping sickness, depends on ergosterol for growth. Here, we describe the effects of a mechanism-based inhibitor, 26-fluorolanosterol (26FL), which converts in vivo to a fluorinated substrate of the sterol C24-methyltransferase essential for sterol methylation and function of ergosterol, and missing from the ...
Leaver, David J. +6 more
openaire +2 more sources
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes
British Journal of Pharmacology, EarlyView.Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley +1 more source
British Journal of Pharmacology, EarlyView.Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo +4 more
wiley +1 more source
Frontiers in Microbiology, 2016 The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol or cycloartenol. This is catalyzed by an oxidosqualene cyclase.
Paul Dahlin +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam +4 more
wiley +1 more source