Results 1 to 10 of about 742,740 (307)

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources [PDF]

Molecules, 2021
Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world.
Alfred Ngenge Tamfu, Selcuk Kucukaydin, Balakyz Yeskaliyeva, Mehmet Ozturk, Rodica Mihaela Dinica   +4 more
doaj   +5 more sources

Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B. [PDF]

Antimicrob Agents Chemother, 2021
Malaria persists as a major health problem due to the spread of drug resistance and the lack of effective vaccines. DNA gyrase is a well-validated and extremely effective therapeutic target in bacteria, and it is also known to be present in the apicoplast of malarial species, including Plasmodium falciparum .
Pakosz Z, Lin TY, Michalczyk E, Nagano S, Heddle JG.   +4 more
europepmc   +4 more sources

A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2

Microorganisms, 2021
The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in serious chaos all over the world.
Seri Jo, Suwon Kim, Jahyun Yoo, Mi-Sun Kim, Dong Hae Shin   +4 more
doaj   +1 more source

Optimization of fucoxanthin extraction obtained from natural by-products from Undaria pinnatifida stem using supercritical CO2 extraction method

Frontiers in Nutrition, 2022
In the recent years, edible brown seaweed, Undaria pinnatifida, has presented beneficial effects, which may be correlated with this species containing major bioactive compounds, such as carotenoids, fatty acids, and phytosterols.
Shipeng Yin, Shipeng Yin, Liqiong Niu, Mario Shibata, Yuanfa Liu, Tomoaki Hagiwara   +5 more
doaj   +1 more source

Pyridazine Based Compounds with PARP-1 Inhibitory Activity

Archives of Pharmaceutical Sciences Ain Shams University, 2023
Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and ...
Norhan A. Abdelrahman, Mai Y. Jaballah, Ahmed A. Al-Karmalawy , Khaled A. M. Abouzid   +3 more
doaj   +1 more source

Structure-activity relationships of fluorene compounds inhibiting HCV variants [PDF]

, 2020
Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths ...
Gadhe, Changdev G., JANG, SUNG KEY, Keum, Gyochang, Kim, Byeong Moon, Kim, Hee Sun, Kohara, Michinori, Lee, Jae Seung, Moon, Heejo, Mun, Jaegon, Pae, Ae Nim, You, Youngsu   +10 more
core   +1 more source

(S)-N-Benzyl-1-phenyl-3,4-dihydroisoqunoline-2(1H)-carboxamide Derivatives, Multi-Target Inhibitors of Monoamine Oxidase and Cholinesterase: Design, Synthesis, and Biological Activity

Molecules, 2023
A series of (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives was synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and-B, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE).
Qing-Hao Jin, Li-Ping Zhang, Shan-Shan Zhang, Dai-Na Zhuang, Chu-Yu Zhang, Zhou-Jun Zheng, Li-Ping Guan   +6 more
doaj   +1 more source

Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea [PDF]

, 2015
Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules.
Carolina Bruno De Sousa, Florêncio Nogueira, Fouzi Mouffouk, Hugo Pereira, José Manuel, João Varela, Khalid M. Abu-salah, Luísa Barreira, Luísa Custódio, Maria João Rodrigues, Marta Oliveira, Nuno Da Rosa Neng, Radhouan Ben-hamadou, Salman A. Alrokayan, The Red Sea   +14 more
core   +7 more sources

Specific quorum sensing-disrupting activity (A(QSI)) of thiophenones and their therapeutic potential [PDF]

, 2015
Disease caused by antibiotic resistant pathogens is becoming a serious problem, both in human and veterinary medicine. The inhibition of quorum sensing, bacterial cell-to-cell communication, is a promising alternative strategy to control disease. In this
Benneche, Tore, Defoirdt, Tom, Scheie, Anne Aamdal, Yang, Qian   +3 more
core   +9 more sources

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In this paper, bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated for their inhibitory activity against α-glucosidase and α-amylase. All synthesised compounds showed potential α-glucosidase and α-amylase inhibitory activities. Compounds 5 g (
Peng-Fei Zheng, Zhuang Xiong, Cui-ying Liao, Xin Zhang, Mei Feng, Xiao-Zheng Wu, Jing Lin, Lin-Sheng Lei, You-Cheng Zhang, Shao-Hua Wang, Xue-Tao Xu   +10 more
doaj   +1 more source