Results 111 to 120 of about 742,740 (307)

A Guideline for Assessment and Characterization of Bacterial Biofilm Formation in the Presence of Inhibitory Compounds. [PDF]

Bio Protoc, 2023
Elgamoudi BA, Korolik V.
europepmc   +1 more source

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule [PDF]

, 2015
Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of ...
Bessa, Cláudia, Bisio, Alessandra, Fernandes, João, Gomes, Célia, Gomes, Sara, Gonçalves, Jorge, Inga, Alberto, Monteiro, Ângelo, Pereira, Clara, Pereira, Nuno A.L., Queiroz, Glória, Raimundo, Liliana, Reis, Flávio, Santos, Maria M.M., Saraiva, Lucília, Soares, Joana   +15 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

In-silico studies of inhibitory compounds against protease enzymes of SARS-CoV-2. [PDF]

Medicine (Baltimore), 2023
Khan S, Nasrullah, Hussain A, Asif M, Sattar FA, Audhal FA, Qadir MI, Hamdard MH.   +7 more
europepmc   +1 more source

Phytochemical Screening and Antibacterial Activity of Leaves Extract Balangla (Litsea cubeba (Lour) Pers.) from Malinau, East Borneo [PDF]

, 2015
Balangla (Litsea cubeba) plant is used as traditional medicine by Dayak Kenyah tribe in East Kalimantan. It contains active compounds that are efficient to treat many human diseases and believed to have an antibacterial activity. The purposes of
Manurung, Hetty, Marina, Elvi, Nugroho, Rudy Agung   +2 more
core   +1 more source

Monoamine Oxidase Inhibitory Effects of Pentanthrene Type Heterocyclic Compounds

YAKUGAKU ZASSHI, 1991
Pentanthrene type heterocyclic compounds, which contain oxazole, isoxazole, oxadiazole, thiazole, isothiazole, thiadiazole or pyrrole ring as C-ring, and naphthalene, quinoline, isoquinoline or quinoxaline ring as A.B-ring, were prepared, and their monoamine oxidase (MAO) inhibitory activities were examined.
A, Noda, H, Noda, T, Imamura, Y, Ono, M, Morita, M, Kai, S, Mine, S, Goto   +7 more
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126. [PDF]

Mar Drugs, 2023
Hao YJ, Zou ZB, Xie MM, Zhang Y, Xu L, Yu HY, Ma HB, Yang XW.   +7 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Analysis of Phytochemical Composition and Biological Activities of Verbascum cheiranthifolium var. cheiranthifolium stem and flowers

International Journal of Secondary Metabolite, 2018
Within this study phytochemical composition, antioxidant and enzyme inhibitory activities of extracts obtained from stem and flower of Verbascum cheiranthifolium var. cheiranthifolium were analysed.
Abdullah Dalar, Aydin Sukru Bengu, Oruc Allahverdiyev   +2 more
doaj   +1 more source