Results 121 to 130 of about 742,740 (307)

Screening of MMV pandemic response and pathogen box compounds against pan-drug-resistant Klebsiella pneumoniae to identify potent inhibitory compounds. [PDF]

New Microbes New Infect, 2023
Sivasankar S, Premnath MA, Boppe A, Grobusch MP, Jeyaraj S.   +4 more
europepmc   +1 more source

Utilization of the water soluable fraction of wheat straw as a plant nutrient source [PDF]

Recovery of water soluble, inorganic nutrients from the inedible portion of wheat was found to be an effective means of recycling nutrients within hydroponic systems.
Garland, J. L., Mackowiak, C. L.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Xanthine oxidase inhibitory activity of compounds from Chythrantus claneianus

Bangladesh Journal of Pharmacology, 2013
Phytochemical investigation of the stem bark and the trunk of Chythrantus claneianus led to the isolation of six known compounds named β-sitosterol (1), umbelliferone (2), scopoletin (3), benjaminamide (4), β-sitosterol-3-O-β-D-glucopyranoside (5) and ...
Anar Sahib Gojayev, Jean Jules Kezetas Bankeu, Angelbert Fusi Awantu, Eric René Sieliatchom Nkanwen, Muhammad Shaiq Ali, Bruno Ndjakou Lenta, Akif Alakbar Guliyev, Didérot Tchamo Noungoué, Silvère Augustin Ngouela, Etienne Tsamo   +9 more
doaj   +1 more source

Indoleamine 2, 3-dioxygenase 1 inhibitory compounds from natural sources. [PDF]

Front Pharmacol, 2022
Tan Y, Liu M, Li M, Chen Y, Ren M.
europepmc   +1 more source

α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines [PDF]

, 2016
α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing ...
DI GIACOMO, Silvia, DI SOTTO, Antonella, El Readi, Mahmoud Zaki, Mazzanti, Gabriela, Wink, Michael   +4 more
core  

Cholinesterase Inhibitory Compounds from Peltophorum Pterocarpum Flowers

Chemistry Africa
AbstractNeurodegenerative disorders (NDs), such as Alzheimer’s and Parkinson disease, affect millions of people worldwide. Natural cholinesterase inhibitors are an important class of lead drugs that have gained much interest for the management of NDs in recent time. They continue to provide promising alternatives to synthetic ones because of their more
James A. Monehin, Ayodeji O. Oriola, Idowu J. Olawuni, Samuel A. Odediran, Olufola O. Ige, Thomas O. Idowu, Abiodun O. Ogundaini   +6 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In silico analysis of angiotensin-converting enzyme inhibitory compounds obtained from soybean [Glycine max (L.) Merr.]. [PDF]

Front Physiol, 2023
Ramlal A, Bhat I, Nautiyal A, Baweja P, Mehta S, Kumar V, Tripathi S, Mahto RK, Saini M, Mallikarjuna BP, Saluja S, Lal SK, Subramaniam S, Fawzy IM, Rajendran A.   +14 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source