Results 51 to 60 of about 428,396 (292)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Cell surface immobilization of GABAARs in cerebellar granule cells depends on the M3/M4 cytoplasmatic loop of the alpha 1 subunit [PDF]

, 2009
Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate brain. The localization of GABA receptors type A (GABAARs) at strategically located domains of the neuronal membrane is of vital importance for fast inhibitory ...
Aránega, Antonia, Boulaiz, Houria, Hooper, Helen, Marchal, Juan A., Perán, Macarena, Rodríguez-Serrano, Fernandez, Salas, Ramiro, Velez, Celia   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Human stem cell-derived neurons establish functional inhibitory–excitatory cortical circuits in a chimeric transplantation model

Scientific Reports
Excitation/inhibition balance is crucial to homeostatic brain function and disrupted in several neurodevelopmental and neurodegenerative diseases.
Cameron P. J. Hunt, Kimberly R. Thek, Jennifer Durnall, Stuart J. McDougall, Clare L. Parish, Carlos W. Gantner   +5 more
doaj   +1 more source

Anatomical identification of a corticocortical top-down recipient inhibitory circuitry by enhancer-restricted transsynaptic tracing

Frontiers in Neural Circuits, 2023
Despite the importance of postsynaptic inhibitory circuitry targeted by mid/long-range projections (e.g., top-down projections) in cognitive functions, its anatomical properties, such as laminar profile and neuron type, are poorly understood owing to the
Yusuke Atsumi, Yusuke Atsumi, Yasuhiro Oisi, Maya Odagawa, Chie Matsubara, Yoshihito Saito, Yoshihito Saito, Hiroyuki Uwamori, Kenta Kobayashi, Shigeki Kato, Kazuto Kobayashi, Masanori Murayama   +11 more
doaj   +1 more source

Robust entropy requires strong and balanced excitatory and inhibitory synapses

, 2018
It is widely appreciated that well-balanced excitation and inhibition are necessary for proper function in neural networks. However, in principle, such balance could be achieved by many possible configurations of excitatory and inhibitory strengths, and ...
Agrawal, Vidit, Alfaori, Qusay, Cowley, Andrew B., Larremore, Daniel B., Restrepo, Juan G., Shew, Woodrow L.   +5 more
core   +1 more source

Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner. [PDF]

, 2017
Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy.
Baraban, Scott C, Hsieh, Jui-Yi
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Distribution and morphology of nitridergic neurons across functional domains of the rat primary somatosensory cortex

Frontiers in Neural Circuits, 2012
The rat primary somatosensory cortex (S1) is remarkable for its conspicuous vertical compartmentalization in barrels and septal columns, which are additionally stratified in horizontal layers.
Anaelli A Nogueira-Campos, Anaelli A Nogueira-Campos, Deborah M Finamore, Luis A Imbiriba, Jean C Houzel, João G Franca   +5 more
doaj   +1 more source