Results 31 to 40 of about 428,396 (292)

The Synaptic Organization of Layer 6 Circuits Reveals Inhibition as a Major Output of a Neocortical Sublamina

Cell Reports, 2019
Summary: The canonical cortical microcircuit has principally been defined by interlaminar excitatory connections among the six layers of the neocortex.
Jaclyn Ellen Frandolig, Chanel Joylae Matney, Kihwan Lee, Juhyun Kim, Maxime Chevée, Su-Jeong Kim, Aaron Andrew Bickert, Solange Pezon Brown   +7 more
doaj   +1 more source

Altered Excitability and Local Connectivity of mPFC-PAG Neurons in a Mouse Model of Neuropathic Pain [PDF]

, 2018
The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects of pain. There is extensive evidence that chronic pain produces functional changes within the mPFC.
Cheriyan, John, Sheets, Patrick L.
core   +1 more source

Timing control by redundant inhibitory neuronal circuits [PDF]

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2014
Rhythms and timing control of sequential activity in the brain is fundamental to cognition and behavior. Although experimental and theoretical studies support the understanding that neuronal circuits are intrinsically capable of generating different time intervals, the dynamical origin of the phenomenon of functionally dependent timing control is still
Tristan, I., Rulkov, N. F., Huerta, R., Rabinovich, M.   +3 more
openaire   +2 more sources

Enriched expression of NF1 in inhibitory neurons in both mouse and human brain

Molecular Brain, 2019
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by loss-of-function mutations in NF1 gene, which encodes a GTPase activating protein for RAS.
Hyun-Hee Ryu, Minkyung Kang, Jinsil Park, Sung-Hye Park, Yong-Seok Lee   +4 more
doaj   +1 more source

3D Clustering of GABAergic Neurons Enhances Inhibitory Actions on Excitatory Neurons in the Mouse Visual Cortex

Cell Reports, 2014
Summary: Neocortical neurons with similar functional properties assemble into spatially coherent circuits, but it remains unclear how inhibitory interneurons are organized. We applied in vivo two-photon functional Ca2+ imaging and whole-cell recording of
Teppei Ebina, Kazuhiro Sohya, Itaru Imayoshi, Shu-Ting Yin, Rui Kimura, Yuchio Yanagawa, Hiroshi Kameda, Hiroyuki Hioki, Takeshi Kaneko, Tadaharu Tsumoto   +9 more
doaj   +1 more source

Functional Interaction Between GABAergic Neurons in the Ventral Tegmental Area and Serotonergic Neurons in the Dorsal Raphe Nucleus

Frontiers in Neuroscience, 2022
GABAergic neurons in the ventral tegmental area (VTA) have brain-wide projections and are involved in multiple behavioral and physiological functions. Here, we revealed the responsiveness of Gad67+ neurons in VTA (VTAGad67+) to various neurotransmitters ...
Sheikh Mizanur Rahaman, Sheikh Mizanur Rahaman, Srikanta Chowdhury, Srikanta Chowdhury, Srikanta Chowdhury, Yasutaka Mukai, Yasutaka Mukai, Daisuke Ono, Daisuke Ono, Hiroshi Yamaguchi, Hiroshi Yamaguchi, Akihiro Yamanaka, Akihiro Yamanaka   +12 more
doaj   +1 more source

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

eLife, 2016
Dravet Syndrome is an intractable form of childhood epilepsy associated with deleterious mutations in SCN1A, the gene encoding neuronal sodium channel Nav1.1.
Yishan Sun, Sergiu P Paşca, Thomas Portmann, Carleton Goold, Kathleen A Worringer, Wendy Guan, Karen C Chan, Hui Gai, Daniel Vogt, Ying-Jiun J Chen, Rong Mao, Karrie Chan, John LR Rubenstein, Daniel V Madison, Joachim Hallmayer, Wendy M Froehlich-Santino, Jonathan A Bernstein, Ricardo E Dolmetsch   +17 more
doaj   +1 more source

Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey

Frontiers in Neural Circuits, 2022
Acetylcholine (ACh) can act on pre- and post-synaptic muscarinic receptors (mAChR) in the cortex to influence a myriad of cognitive processes. Two functionally-distinct regions of the prefrontal cortex—the lateral prefrontal cortex (LPFC) and the ...
Alexandra Tsolias, Maria Medalla, Maria Medalla   +2 more
doaj   +1 more source

An inhibitory pull-push circuit in frontal cortex. [PDF]

, 2017
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons.
AA Zekveld, CK Pfeffer, CM Niell, D Huber, Dario L Ringach, DS Greenberg, Elaine Tring, HJ Pi, I Ozden, JJ Letzkus, Joshua T Trachtenberg, JS Anderson, L Petreanu, M Vinck, MJ McGinley, MM Karnani, Pablo Garcia-Junco-Clemente, PJ Mineault, PO Polack, RB Ebitz, RJ Douglas, S Lee, SL Smith, Taruna Ikrar, TW Chen, Xiangmin Xu, Y Fu   +26 more
core   +1 more source

Cortical Plasticity Induced by Inhibitory Neuron Transplantation [PDF]

Science, 2010
Inflexible Timing for Flexibility During critical periods in early life, sensory experience molds circuits in the brain. In the visual cortex, blurring or occluding vision in one eye triggers a rapid reorganization of neuronal responses known as ocular dominance plasticity.
Derek G, Southwell, Robert C, Froemke, Arturo, Alvarez-Buylla, Michael P, Stryker, Sunil P, Gandhi   +4 more
openaire   +2 more sources