Results 31 to 40 of about 248,879 (259)
eLife, 2016 Dravet Syndrome is an intractable form of childhood epilepsy associated with deleterious mutations in SCN1A, the gene encoding neuronal sodium channel Nav1.1.
Yishan Sun +17 more
doaj +1 more source
Nature Communications, 2021 Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.
Ilary Allodi +4 more
doaj +1 more source
IMPAIRED PROCESSING IN THE PRIMARY AUDITORY CORTEX OF AN ANIMAL MODEL OF AUTISM
Frontiers in Systems Neuroscience, 2015 Autism is a neurodevelopmental disorder clinically characterized by deficits in communication, lack of social interaction and, repetitive behaviors with restricted interests.
Renata eAnomal +5 more
doaj +1 more source
Cell-type-specific responses to associative learning in the primary motor cortex
eLife, 2022 The primary motor cortex (M1) is known to be a critical site for movement initiation and motor learning. Surprisingly, it has also been shown to possess reward-related activity, presumably to facilitate reward-based learning of new movements.
Candice Lee +4 more
doaj +1 more source
Cell Reports, 2017 Integrative brain functions depend on widely distributed, rhythmically coordinated computations. Through its long-ranging connections with cortex and most senses, the thalamus orchestrates the flow of cognitive and sensory information.
Alexandra Clemente-Perez +12 more
doaj +1 more source
CHAOS AND STABILITY IN A MODEL OF INHIBITORY NEURONAL NETWORK [PDF]
International Journal of Bifurcation and Chaos, 2010 We analyze the dynamics of a deterministic model of inhibitory neuronal networks proving that the discontinuities of the Poincaré map produce a never empty chaotic set, while its continuity pieces produce stable orbits. We classify the systems in three types: the almost everywhere (a.e.) chaotic, the a.e. stable, and the combined systems.
openaire +2 more sources
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Frontiers in Computational Neuroscience, 2013 Fruit flies (Drosophila melanogaster) rely on their olfactory system to process environmental information. This information has to be transmitted without system-relevant loss by the olfactory system to deeper brain areas for learning.
Faramarz eFaghihi +4 more
doaj +1 more source
Frontiers in Neural Circuits, 2023 Despite the importance of postsynaptic inhibitory circuitry targeted by mid/long-range projections (e.g., top-down projections) in cognitive functions, its anatomical properties, such as laminar profile and neuron type, are poorly understood owing to the
Yusuke Atsumi +11 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source