Results 111 to 120 of about 105,210 (313)

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

open access: yesAdvanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang   +19 more
wiley   +1 more source

Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3R451C Mouse Model of Autism

open access: yesFrontiers in Cellular Neuroscience, 2018
Understanding neuronal mechanisms underlying aggression in patients with autism spectrum disorder (ASD) could lead to better treatments and prognosis.
Suzanne Hosie   +8 more
doaj   +1 more source

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

open access: yesAdvanced Science, EarlyView.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou   +14 more
wiley   +1 more source

Artificial Nervous Systems

open access: yesAdvanced Science, EarlyView.
By drawing inspiration from biological neural hierarchies and the working mechanisms of plasticity, researchers have constructed a series of bionic devices, including sensory devices, synapse devices, and artificial neural systems. They committed to simulating and surpassing the biological information processing function, thereby realizing the ...
Lu Yang   +5 more
wiley   +1 more source

Novel Optoelectronic Reconfigurable Transistors Based on Graphene/VO2 Heterojunction for Efficient Neuromorphic Perception, Computation, and Storage

open access: yesAdvanced Science, EarlyView.
A novel optoelectronic reconfigurable neuromorphic transistor based on a graphene/VO2 heterojunction with inserted Au electrodes is proposed. It exhibits broad‐spectrum self‐powered photodetection capability ranging from 365 to 940 nm. Through bias control and electrode sizing strategies, multiple functions for switch, synapse, and storage are achieved,
Danke Chen   +10 more
wiley   +1 more source

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