Results 201 to 210 of about 105,210 (313)

Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice

open access: yesVIEW, EarlyView.
The mechanisms underlying neurodevelopmental toxicity induced by repeated exposure to general anesthesia in neonatal mice remain to be fully elucidated. In this study, neonatal mice were exposed to sevoflurane on postnatal days 6, 8, and 10. On postnatal day 30, the medial prefrontal cortex was collected for whole‐genome bisulfite sequencing and RNA ...
Yu Hou   +10 more
wiley   +1 more source

The emergence of electrical activity in human brain organoids. [PDF]

open access: yesStem Cell Reports
Mancinelli S, Bariselli S, Lodato S.
europepmc   +1 more source

Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery   +43 more
wiley   +1 more source

Cl‐ ‐ and K+‐dependent inhibitory postsynaptic potentials evoked by interneurones of the rat lateral geniculate nucleus.

open access: bronze, 1988
Vincenzo Crunelli   +4 more
openalex   +1 more source

Tau Axonal Sorting and Interaction With Synaptic Plasticity Modulators Is Domain‐ and Isoform‐Dependent in Human iPSC‐Derived Neurons

open access: yesAging Cell, EarlyView.
Efficient axonal Tau sorting requires the PRR2 domain but does not depend on AT8 or KXGS phosphorylation, the MT affinity, the C‐terminal repeat domains, or the N‐terminal tail of Tau. Human 0N4R‐Tau shows isoform‐specific interaction with modulators of synaptic plasticity involved in spine function under both normal and AD conditions.
Michael Bell‐Simons   +7 more
wiley   +1 more source

Alpha‐Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease

open access: yesAging Cell, EarlyView.
This schematic illustration summarizes the effects of calcium alpha‐ketoglutarate (CaAKG) on synaptic plasticity in a mouse model of Alzheimer's disease (APP/PS1). CaAKG enhances autophagy and restores LTP in APP/PS1 mice via NMDAR‐independent, LTCC, and CPAMPAR‐dependent pathways.
Sheeja Navakkode, Brian K. Kennedy
wiley   +1 more source

Home - About - Disclaimer - Privacy