The Journal of Physiology, EarlyView.Abstract figure legend Neuromuscular disuse scenarios of limb immobilization, reduced activity and bed rest result in impairments of muscle strength that exceed losses of muscle size. Neural adaptations are an assured consequence of disuse. The available evidence garnered from human and animal models highlights suppressed motor unit firing rate (MUFR ...
Mathew Piasecki
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen +4 more
wiley +1 more source
Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models. [PDF]
Genom PsychiatryFudge JL, Kelly EA, Mahoui I.
europepmc +1 more source
Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity
The Journal of Physiology, EarlyView.Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez +3 more
wiley +1 more source
Exploring neuronal mechanisms of osteosarcopenia in older adults
The Journal of Physiology, EarlyView.Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic ...
Ilhan Karacan, Kemal Sıtkı Türker
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Impaired Presynaptic Function Contributes Significantly to the Pathology of Glycine Receptor Autoantibodies. [PDF]
Neurol Neuroimmunol NeuroinflammWiessler AL +7 more
europepmc +1 more source
Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise
The Journal of Physiology, EarlyView.Abstract figure legend This study unveiled the essential role of the orexinergic nervous system in the central circuitry that transmits central command signals for locomotor exercise. We observed the excitation of orexinergic neurons by voluntary locomotor exercise in rats.
Emi Narai +7 more
wiley +1 more source
A computational account of joint SSRI and anti-inflammatory treatment. [PDF]
Front ImmunolReneaux M +3 more
europepmc +1 more source
Early adversity and the comorbidity between metabolic disease and psychopathology
The Journal of Physiology, EarlyView.Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source
Alternatively spliced mini-exon B in PTPδ regulates excitatory synapses through cell-type-specific trans-synaptic PTPδ-IL1RAP interaction. [PDF]
Nat CommunKim S +13 more
europepmc +1 more source