Results 251 to 260 of about 108,206 (318)

Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients

Epilepsia, EarlyView.
The K⁺/Cl− cotransporter (KCC2) limits induced ictal‐like events and their spread in the supragranular layer of human neocortical slices from the seizure‐propagation zone of temporal lobe epilepsy patients. Cl⁻ extrusion is present in supragranular pyramidal neurons but limited under high somatic Cl⁻ load.
Alice Falck, Janna Lehnhoff, Mahraz Behbood, Egor Byvaltcev, Annette Aigner, Helena Radbruch, Pawel Fidzinski, Jan‐Hendrik Schleimer, Gabriel M. S. Janach, Noah Döhne, Julia Onken, Thilo Kalbhenn, Thomas Sauvigny, Rudolf A. Deisz, Susanne Schreiber, Martin Holtkamp, Ulf Strauss   +16 more
wiley   +1 more source

Glia Preferentially Gobble on GABAergic Neurons. [PDF]

Epilepsy Curr
Varvel NH.
europepmc   +1 more source

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Incremental self-organization of spatio-temporal spike pattern detection. [PDF]

Sci Rep
Dehghani Habibabadi M, Müller L, Pawelzik K.   +2 more
europepmc   +1 more source

Zebrafish models of developmental epileptic encephalopathy accurately reflect clinical electrographic biomarkers

Epilepsia, EarlyView.
Abstract Objective Developmental epileptic encephalopathies (DEEs) are epilepsy conditions characterized by significant severity and treatment challenges. Spectral components of the encephalogram (EEG) may provide a valuable biomarker of epileptic severity.
Paige Whyte‐Fagundes, Joseane Righes Marafiga, Bingyao Zhu, Scott C. Baraban   +3 more
wiley   +1 more source

Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation). [PDF]

Elife
Isbister JB, Ecker A, Pokorny C, Bolaños-Puchet S, Egas Santander D, Arnaudon A, Awile O, Natali BZ, Alonso JB, Boci E, Chindemi G, Courcol JD, Damart T, Delemontex T, Dietz A, Ficarelli G, Gevaert M, Herttuainen J, Ivaska G, Ji W, Keller D, King J, Kumbhar P, Lapere S, Litvak P, Mandge D, Muller EB, Pereira F, Planas J, Ranjan R, Reva M, Romani A, Rössert C, Schürmann F, Sood V, Teska A, Tuncel A, Van Geit W, Wolf M, Markram H, Ramaswamy S, Reimann MW.   +41 more
europepmc   +1 more source

Loss of the Mecp2 gene in parvalbumin interneurons leads to an inhibitory deficit in the amygdala and affects its functional connectivity. [PDF]

Mol Autism
Liiwand M, Haikonen J, Kokinovic B, Molchanova SM, Aitta-Aho T, Lauri SE, Ryazantseva M.   +6 more
europepmc   +1 more source

Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABA_B Receptor Signaling. [PDF]

J Neurosci
Mäki-Marttunen T, Kismul JF, Pajo K, Schulz JM, Manninen T, Einevoll GT, Linne ML, Andreassen OA, Kotaleski JH.   +8 more
europepmc   +1 more source

Excitatory/Inhibitory balance in autism spectrum disorders: Integrating genetic, neurotransmitter and computational perspectives. [PDF]

AIMS Neurosci
Madia D, Sheikh M, Pethe A, Telange D, Agrawal S.   +4 more
europepmc   +1 more source