Results 251 to 260 of about 276,610 (317)

Modeling neuron-astrocyte interactions in neural networks using distributed simulation. [PDF]

PLoS Comput Biol
Jiang HJ, Aćimović J, Manninen T, Ahokainen I, Stapmanns J, Lehtimäki M, Diesmann M, van Albada SJ, Plesser HE, Linne ML.   +9 more
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Spinal Calcrl+ neurons amplify mechanical itch signaling via synaptic plasticity in chronic itch model. [PDF]

PLoS One
Jiao H, Dai Q, Li Z, Yuan M, Xu G, Tian Y, Su G, Zhang Y, Sun C, Wang S, Ma C, Pan H.   +11 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Proximity labeling uncovers the synaptic proteome under physiological and pathological conditions. [PDF]

Front Cell Neurosci
Matsubayashi J, Takano T.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline. [PDF]

J Neuroinflammation
Portugal CC, Almeida TO, Tedim-Moreira J, Silva C, Canedo T, Galvão J, Magalhães A, Summavielle T, Bai X, Kirchhoff F, Rubinstein B, Moreira I, Costa J, Guedes J, Pinto IM, Peça J, Socodato R, Relvas JB.   +17 more
europepmc   +1 more source

Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation

Biological Reviews, EarlyView.
ABSTRACT The nervous system's capacity to process complex stimuli has long intrigued neuroscientists, with multiplexing now recognized as a fundamental neural coding strategy. Multiplexing refers to the simultaneous encoding of multiple stimulus features via vi distinct components of neuronal responses, such as firing rates and precise temporal spike ...
Mohammad Amin Kamaleddin
wiley   +1 more source

The development of functional glutamatergic and GABAergic synaptic connections between vestibulo-ocular projection neurons and oculomotor motoneurons in the chicken embryo. [PDF]

Front Neurol
Mochida H, Glover JC.
europepmc   +1 more source

Impact of Prior Intravenous Immunoglobulin and Plasmapheresis on Eculizumab or Ravulizumab Treatment for Generalized Myasthenia Gravis: An Analysis of the MG SPOTLIGHT Registry

Clinical and Experimental Neuroimmunology, EarlyView.
ABSTRACT Objective The complement component 5 inhibitor therapies (C5ITs) eculizumab and ravulizumab are approved for the treatment of generalized myasthenia gravis (gMG). We evaluated the real‐world effectiveness and safety of eculizumab and ravulizumab in patients with gMG with or without prior intravenous immunoglobulin (IVIg) or plasma exchange ...
Akiyuki Uzawa, Ema Rodrigues, Hiroyuki Murai   +2 more
wiley   +1 more source