Results 31 to 40 of about 9,333,976 (340)

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
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Performance of the nonlinear inhibitory plasticity rule under varying postsynaptic firing rate with dynamic excitatory and inhibitory LTD/LTP threshold matching.

, 2022
A. Adding noise to the postsynaptic firing rate. Top: E-to-E (wEE, blue) and I-to-E (wEI, red) as a function of time. Middle: Excitatory (, blue) and inhibitory (, red) postsynaptic LTD/LTP threshold as a function of time.
Julijana Gjorgjieva (255641), Christoph Miehl (8816756)   +1 more
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Membrane-derived phospholipids control synaptic neurotransmission and plasticity. [PDF]

PLoS Biology, 2015
Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics have been poorly understood.
Victoria García-Morales, Fernando Montero, David González-Forero, Guillermo Rodríguez-Bey, Laura Gómez-Pérez, María Jesús Medialdea-Wandossell, Germán Domínguez-Vías, José Manuel García-Verdugo, Bernardo Moreno-López   +8 more
doaj   +1 more source

The influence of GABAergic signaling on dendritic processing [PDF]

, 2013
GABAergic (?-aminobutyric acid-releasing) signaling plays a crucial role in integration processes of pyramidal neurons. Specific subtypes of GABA releasing interneurons innervate different compartments of pyramidal neurons; thereby modulating the ...
Willadt, Silvia
core   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Ten Bruggencate, Gerrit, Galvan, Martin, Grafe, Peter   +2 more
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Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses

, 2023
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites.
Dean J. Kareemo, Samantha S. Olah, William C. Buchta, Matthew J. Kennedy, Kevin C. Crosby, Jason Aoto, Hannah S. Actor-Engel, Brooke L. Sinnen, Sara E. Gookin, Christina S. Winborn, Katharine R. Smith, Carley N. Miller, Mason S. Kleinjan   +12 more
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Single dendrite-targeting interneurons generate branch-specific inhibition.

Frontiers in Neural Circuits, 2014
Microcircuits composed of dendrite-targeting inhibitory interneurons and pyramidal cells are fundamental elements of cortical networks, however, the impact of individual interneurons on pyramidal dendrites is unclear.
Caleb eStokes, Corinne eTeeter, Jeffry eIsaacson   +2 more
doaj   +1 more source

Emergence of beta/gamma oscillations: ING, PING, and what about RING? [PDF]

, 2011
Poster presentation from Twentieth Annual Computational Neuroscience Meeting: CNS*2011 Stockholm, Sweden. 23-28 July 2011. Background: Oscillatory activity in high-beta and gamma bands (20-80Hz) is known to play an important role in cortical processing ...
Moca, Vasile V., Raul C Mureşan, Mureşan, Raul C., Vasile V Moca, Mureşan Raul C, Moca Vasile V   +5 more
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Dynamic matching of the excitatory and inhibitory postsynaptic LTD/LTP thresholds.

, 2022
A. Plasticity curves of E-to-E (, blue) and I-to-E (, red) weights as a function of the postsynaptic rate νE with static, non-identical LTD/LTP thresholds (, ). B.
Julijana Gjorgjieva (255641), Christoph Miehl (8816756)   +1 more
core   +1 more source

Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity [PDF]

, 2022
International audienceGephyrin ( GPHN ) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology of neuropsychiatric disorders.
Ango, Fabrice, Reis, R., Kornobis, Etienne, Allemand, Eric, Carrasco Sala, J., Tores, Frederic, Schlosser, A., Maric, H., Nitschké, Patrick, Carrasco, Judit, Kornobis, E., Ango, F., Tores, F., Nitschké, P., Jahannault-Talignani, Céline, Muchardt, Christian, Maric, Hans Michael, Gautier, Candice, Jahannault-Talignani, C., Gautier, C., Muchardt, C., Pereira, A., Allemand, E., dos Reis, Raphaël, Pereira, Alyssa, Schlosser, Andreas, Patrick Nitschké, Christian Muchardt, Judit Carrasco, Andreas Schlosser, Candice Gautier, Etienne Kornobis, Fabrice Ango, Frederic Tores, Raphaël Dos Reis, Hans Michael Maric, Eric Allemand, Céline Jahannault-Talignani, Alyssa Pereira   +38 more
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