Results 81 to 90 of about 108,180 (299)

A Markovian event-based framework for stochastic spiking neural networks

, 2011
In spiking neural networks, the information is conveyed by the spike times, that depend on the intrinsic dynamics of each neuron, the input they receive and on the connections between neurons. In this article we study the Markovian nature of the sequence
A Delorme, A Delorme, A Holden, A Lachal, A Lachal, A Roxin, A Tonnelier, Arbib, B Cessac, C Fricker, E Claverol, E Gobet, E Kandel, E Rolls, EM Izhikevich, H Gromoll, HC Tuckwell, HP McKean, I Karatzas, J Touboul, J Touboul, Jonathan D. Touboul, L Ricciardi, L Watts, M Cottrell, M Cottrell, M Davis, M Fabre-Thorpe, M Goldman, M Rudolph, MN Shadlen, N Brunel, Olivier D. Faugeras, P Kloeden, R Brette, R Brette, R Brette, S Asmussen, S Thorpe, T Makino, T Turova, TS Turova, W Gerstner, W Gerstner, WR Softky   +44 more
core   +3 more sources

Neural mechanisms of social learning in the female mouse [PDF]

, 2017
Social interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones of the stud male that alters neuroendocrine responses to his chemosignals for many weeks.
Abraham, Abraham, Arnson, Bakker, Barkai, Barth, Ben-Shaul, Brennan, Brennan, Brennan, Brennan, Brennan, Brennan, Bruce, Burns-Cusato, Caligioni, Castro, Chamero, Clancy, Daoudal, Desai, Dietz, Dulac, Dulac, Fan, Guenthner, Halem, Harvey, Hendrickson, Hull, Hurst, Ichikawa, Isaacson, Kaba, Kaba, Kendrick, Keverne, Kimchi, Lee, Li, Lin, Luo, Lévy, Mak, Margrie, Matsuoka, Matsuoka, Matsuoka, Meeks, Mozzachiodi, Nolan, Nolan, Preston, Reijmers, Reijmers, Ross, Rosser, Sakurai, Shepherd, Shingo, Shpak, Shpak, Stackman, Stowers, Ström, Tachikawa, Takahashi, Tirindelli, Tolokh, Turrigiano, Wallace, Wang, Wang, Wang, Wu, Yassin, Yiu, Young, Zhang, Zhou   +79 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Effects of Methylphenidate on the Inhibitory Postsynaptic Potential in Rat Locus Coeruleus Neurons.

The Kurume Medical Journal, 2002
Effects of methylphenidate (MPH), an agent used clinically for the treatment of children presenting the attention-deficit/hyperactivity disorder (AD/HD), on synaptic transmission in the rat locus coeruleus (LC) were examined by intracellular recording methods.
Takashi, Kuwahata, Masaru, Ishimatsu, Yuri, Kidani, Takashi, Akasu   +3 more
openaire   +3 more sources

Double Inverse Stochastic Resonance with Dynamic Synapses

, 2016
We investigate the behavior of a model neuron that receives a biophysically-realistic noisy post-synaptic current based on uncorrelated spiking activity from a large number of afferents.
Barreto, E., Ozer, M., So, P., Torres, J. J., Uzuntarla, M.   +4 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific

Frontiers in Cellular Neuroscience, 2011
Paired pre- and postsynaptic activity in area CA1 of the hippocampus induces long-term inhibitory synaptic plasticity at GABAergic synapses. This pairing-induced GABAergic plasticity weakens synaptic inhibition due to a depolarization of the reversal ...
Jake eOrmond, Jake eOrmond, Melanie A Woodin   +2 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo.

PLoS Biology, 2020
Modeling the processes of neuronal progenitor proliferation and differentiation to produce mature cortical neuron subtypes is essential for the study of human brain development and the search for potential cell therapies. We demonstrated a novel paradigm
Yingchao Shi, Le Sun, Mengdi Wang, Jianwei Liu, Suijuan Zhong, Rui Li, Peng Li, Lijie Guo, Ai Fang, Ruiguo Chen, Woo-Ping Ge, Qian Wu, Xiaoqun Wang   +12 more
doaj   +1 more source

Associative properties of structural plasticity based on firing rate homeostasis in recurrent neuronal networks

, 2018
Correlation-based Hebbian plasticity is thought to shape neuronal connectivity during development and learning, whereas homeostatic plasticity would stabilize network activity.
Gallinaro, Júlia V, Rotter, Stefan
core   +2 more sources