Results 141 to 150 of about 1,498,031 (298)

Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion. [PDF]

JCI Insight, 2022
Myers JA, Schirm D, Bendzick L, Hopps R, Selleck C, Hinderlie P, Felices M, Miller JS.   +7 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9. [PDF]

Cancers (Basel), 2023
Chan C, Lustig M, Jansen JHM, Garcia Villagrasa L, Raymakers L, Daamen LA, Valerius T, van Tetering G, Leusen JHW.   +8 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized “Inhibisome” Clusters

, 2011
Receptors with activating motifs are captured in inhibitory intracellular compartments and thereby prevented from signaling.
Julien Claver, Meetu Tiwari, Séverine Pfirsch-Maisonnas, Meryem Aloulou, Ting Xu, Renato C. Monteiro, Yutaka Kanamaru, Pierre Launay, Ulrich Blank   +8 more
core   +1 more source

Inhibitory Receptors and Their Modes of Action

Cold Spring Harbor Symposia on Quantitative Biology, 1999
D C, Fong, J C, Cambier
openaire   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Inhibitory receptor states, immune homeostasis and the benefit–risk boundary of cancer checkpoint blockade

Frontiers in Immunology
Immune checkpoint blockade has transformed cancer treatment, but its clinical success depends on releasing antitumor immunity without collapsing peripheral tolerance.
Xiaodong Wang, Wei Gao, Qianqian Wang, Songjiang He, Songli Cui, Bingchen Duan, Gouping Ding, Yiping Huang, Bingwen Zou   +8 more
doaj   +1 more source

Nanoscale Colocalization of NK Cell Activating and Inhibitory Receptors Controls Signal Integration. [PDF]

Front Immunol, 2022
Tomaz D, Pereira PM, Guerra N, Dyson J, Gould K, Henriques R.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source