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Deconstructing iNKT cell development at single-cell resolution
Trends in Immunology, 2022Invariant natural killer T (iNKT) cells are increasingly regarded as disease biomarkers and immunotherapeutic targets. However, a greater understanding of their biology is necessary to effectively target these cells in the clinic. The discovery of iNKT1/2/17 cell effector subsets was a milestone in our understanding of iNKT cell development and ...
Thomas Baranek +2 more
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, 2014 Natural killer T cells (NKT) are T lymphocytes with a reactivity directed against glycolipid antigens presented by MHC-like CD1d molecules expressed by antigen presenting cells (APC). A large proportion of these cells (invariant NKT cells (iNKT)) possess strong immunomodulatory properties which impose a profound impact on the development and course of ...
S. Bondarenko
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Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting [PDF]
Cancer Cell, 2018 Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19-engineering of the CD1d-restricted invariant natural killer T (iNKT) cells would result ...
Antonia Rotolo +2 more
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The interaction between iNKT cells and B cells
Journal of Leukocyte Biology, 2021AbstractInvariant natural killer T cells (iNKTs) bridge the innate immunity with the adaptive immunity and their interaction with B cells has been extensively studied. Here, we give a complete overview of these two cells, from their mechanism of interaction to clinical prospects and existing problems.
Tong, Zhu +9 more
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A nano-engager for iNKT cells in cancer
Nature Cancer, 2020Invariant natural killer T cells (iNKT cells) are innate-like CD1d-restricted T cells that have NK cell–like properties and bear an invariant T cell receptor (iTCR). iNKT cells have shown potential for cancer immunotherapy. A study now shows that stabilization of the iTCR–CD1d complex via a single-chain bi-specific antibody stimulates iNKT cell ...
Mark A. Exley +2 more
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iNKT-Cell Responses to Glycolipids
Critical Reviews in Immunology, 2005Invariant natural killer T (iNKT) cells are an unusual group of T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related protein CD1d. Because iNKT cells play a regulatory role in the immune system, they are attractive targets for immunotherapy.
Vrajesh V, Parekh +2 more
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Adjuvant activity mediated by iNKT cells
Seminars in Immunology, 2010Invariant natural killer T (iNKT) cells have adjuvant activity due to their ability to produce large amounts of IFN-gamma, which activates other cells in innate and acquired systems, and orchestrates protective immunity. Based on these adjuvant mechanisms, we developed iNKT cell-targeted adjuvant therapy and carried out a phase I/IIa trial on advanced ...
Shinichiro, Fujii +5 more
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iNKT Cells in Allergic Disease
2007Recent studies indicate that invariant TCR+ CD1d-restricted natural killer T (iNKT) cells play an important role in regulating the development of asthma and allergy. iNKT cells can function to skew adaptive immunity toward Th2 responses, or can act directly as effector cells at mucosal surfaces in diseases such as ulcerative colitis and bronchial ...
E H, Meyer, R H, DeKruyff, D T, Umetsu
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Mechanism of regulation of autoimmunity by iNKT cells
Cytokine, 2011iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The capacity of iNKT cells to produce regulatory cytokines first provided an indication of their regulatory potential. Later on, in experimental models as well as in patients afflicted with an auto-immune disease, such as Type 1 diabetes mellitus, multiple sclerosis ...
Jan, Novak, Agnes, Lehuen
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Clinical Immunology, 2019
Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and promote anti-tumor and anti-pathogen immunity.
Mohammad, Fereidouni +2 more
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Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and promote anti-tumor and anti-pathogen immunity.
Mohammad, Fereidouni +2 more
openaire +2 more sources