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Basic Techniques for Studies of iNKT Cells and MAIT Cells

2014
Invariant natural killer T (iNKT) cells and mucosal-associated invariant T cells (MAIT cells) are T cell subsets belonging to innate-like lymphocytes. These innate-like lymphocytes express semi-invariant T cell receptors, but exert diverse functions and thus are involved in various types of immune responses. As iNKT cells and MAIT cells are abundant in
Asako, Chiba, Sachiko, Miyake
openaire   +2 more sources

Innate Regulatory iNKT Cells

2008
The complexity of the immune system requires mechanisms, cellular and molecular, that coordinate early innate immune responses to those of late adaptive immune responses. One type of immune cell that is able to mediate this bridge between innate immunity and adaptive immunity is the invariant natural killer T (iNKT) cell. In recent years, much research
Dalam Ly, Terry L. Delovitch
openaire   +1 more source

iNKT cells need UTX-tra demethylation

Nature Immunology, 2017
The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells.
S Harsha, Krovi, Laurent, Gapin
openaire   +2 more sources

Ligation of iNKT TCRs as a novel approach to activate iNKT cells for cancer immunotherapy

The Journal of Immunology, 2017
Abstract Invariant natural killer T (iNKT) cells are innate-like T cells with an invariant TCRa chain and are restricted by CD1d. The activation of iNKT cells has demonstrated potent anti-tumor activity. Current anti-tumor clinical trials using the iNKT cell ligand, a-galactosylceramide (a-GalCer) have had limited success.
Weiming Yuan   +2 more
openaire   +1 more source

iNKT cells for allogeneic cell therapy

Cell and Gene Therapy Insights, 2023
Eleni Chantzoura, Paul Ibbett
openaire   +1 more source

High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision

Cell Reports, 2020
Carolina De Amat Herbozo   +2 more
exaly  

iNKT cell autoreactivity: what is 'self' and how is it recognized?

Nature Reviews Immunology, 2010
Laurent Gapin, Gapin Laurent
exaly  

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