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Macrophages make the bed for early iNKT cells
Nature Immunology, 2021Colonization of the mucosal tissues by iNKT cells was thought to be linked to the first contact with the environment. New research demonstrates that this process is regulated by and dependent on embryonic macrophages.
Léo Bertrand +2 more
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Genetic Analysis of iNKT Cell Development and Function
2021Natural killer T (NKT) cells are among the immediate and early responding immune cells and are important players in autoimmune diseases and tumor immunity. This unique subset of T cells shares properties of natural killer cells and T cells. Proper identification and characterization of NKT cell subsets is essential to understand the function and ...
Julie, Sahler +5 more
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iNKT Cells: Innate Lymphocytes with a Diverse Response
Critical Reviews in Immunology, 2014It is now established that natural killer T (NKT) cells can influence adaptive immune responses by producing vast amounts of cytokines. Different subsets of NKT cells with distinctive functional characteristics regarding cytokine production have been described.
Monteiro, Marta, Graca, Luis
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Activation and Function of iNKT and MAIT Cells
2015Over the last two decades, it has been established that peptides are not the only antigens recognized by T lymphocytes. Here, we review information on two T lymphocyte populations that recognize nonpeptide antigens: invariant natural killer T cells (iNKT cells), which respond to glycolipids, and mucosal associated invariant T cells (MAIT cells), which ...
Shilpi, Chandra, Mitchell, Kronenberg
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Expansion of Human iNKT Cells Ex Vivo
2021Invariant natural killer T (iNKT) cells are credited with antitumor activity by preclinical studies and clinical trials. Efficient expansion of iNKT cells ex vivo is essential for their translational usage. The culturing procedure described here provides an optimized method for ex vivo expansion of iNKT cells using recombinant human IL-15 (rhIL-15) and
Jing, Wang, Chen, Zhao, Jianqing, Xu
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GVHD protection? ThiNK iNKT cells
Blood, 2012In this issue of Blood , Rubio et al report that posttransplant invariant NKT (iNKT) cell recovery is inversely correlated with the risk of developing GVHD after stem cell transplantation ...
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The Expansion and Cytotoxicity Detection of Human iNKT Cells
2021Invariant natural killer T (iNKT) cell is a type of innate-like T cell subsets with both T and NK cell phenotype and functions. They recognize lipid antigens presented by CD1d molecules and can be specifically activated by alpha-galactosylceramide (α-GalCer) in vitro.
Xue, Cheng +4 more
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Expression of functional GPR35 in human iNKT cells
Biochemical and Biophysical Research Communications, 2010The aim of this study was to examine the expression of G protein-coupled receptor (GPR)35 in human invariant natural killer T (iNKT) cells and to determine the functional effects induced by selective activation of this receptor. RT-PCR analysis showed that both human iNKT cells and resting PBMC expressed GPR35; GPR35 protein resulted mostly localized ...
FALLARINI, Silvia +4 more
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iNKT cells do a fat lot of good
Nature Immunology, 2016Altered signaling via the T cell antigen receptor (TCR) promotes an adipose-tissue-like phenotype in invariant natural killer cells (iNKT cells) during thymic development and causes selective enrichment for iNKT cells in adipose tissues.
Jayati, Mookerjee-Basu +1 more
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Science Signaling, 2012
Invariant natural killer T cells produce anti-inflammatory cytokines in the adipose tissue and protect against diet-induced obesity.
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Invariant natural killer T cells produce anti-inflammatory cytokines in the adipose tissue and protect against diet-induced obesity.
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