Results 201 to 210 of about 219,914 (245)

Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE [PDF]

open access: yesCellular and Molecular Immunology, 2019
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) in which the immune system damages the protective insulation surrounding the nerve fibers that project from neurons. A hallmark of MS and its animal model, experimental autoimmune encephalomyelitis (EAE), is autoimmunity against proteins of the myelin sheath ...
Luc Van Kaer, Lan Wu, Chuan Wang
exaly   +3 more sources

Innate and Innate-like Effector Lymphocytes in Health and Disease

The Journal of Immunology, 2022
Abstract Lymphocytes can be functionally partitioned into subsets belonging to the innate or adaptive arms of the immune system. Subsets of innate and innate-like lymphocytes may or may not express Ag-specific receptors of the adaptive immune system, yet they are poised to respond with innate-like speed to pathogenic insults but lack ...
Luc Van Kaer   +3 more
openaire   +2 more sources

Genomic and Transcriptional Mechanisms Governing Innate-like T Lymphocyte Development

The Journal of Immunology, 2022
Abstract Innate-like lymphocytes are a subset of lymphoid cells that function as a first line of defense against microbial infection. These cells are activated by proinflammatory cytokines or broadly expressed receptors and are able to rapidly perform their effector functions owing to a uniquely primed chromatin state that is acquired as
Roxroy C Morgan, Barbara L Kee
openaire   +2 more sources

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