Results 211 to 220 of about 219,914 (245)
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A shared gene‐expression signature in innate‐like lymphocytes
Immunological Reviews, 2005Summary: Innate and adaptive immunities are the two major arms of the immune system, which rely on distinct cell types. These cells can be distinguished not only by the source of diversity for non‐self recognition, of germline or somatic origin, but also by their localization and the pattern and rates of response after encounter of antigenic triggers.
Tetsuya, Yamagata +2 more
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Consequence of the SLAM-SAP Signaling Pathway in Innate-like and Conventional Lymphocytes [PDF]
Immunity, 2007 Signaling lymphocytic activation molecule (SLAM) family receptors mediate important regulatory signals in immune cells, as a result of their exquisite ability to associate with members of the SLAM-associated protein (SAP) family of adaptors. As discussed herein, recent findings show that the SLAM and SAP families carry out pivotal functions in innate ...
Sylvain Latour +2 more
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Role of SLAM Family Receptors and Specific Adapter SAP in Innate-Like Lymphocytes
Critical Reviews in Immunology, 2014Innate-like lymphocytes, which comprise an integral part of the immune system, possess unique developmental and functional capabilities that set them apart from conventional T and B lymphocytes. Strategically located to act as a first line of defense against pathogens, they behave as innate cells.
Pablo Engel, Jordi Sintes, Xavier Romero
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Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma
Clinical Reviews in Allergy & Immunology, 2019Asthma is a chronic pulmonary disease, highly associated with immune disorders. The typical symptoms of asthma include airway hyperresponsiveness (AHR), airway remodeling, mucus overproduction, and airflow limitation. The etiology of asthma is multifactorial and affected by genetic and environmental factors. Increasing trends toward dysbiosis, smoking,
Chao Huang +3 more
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Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]
Nature Reviews Immunology, 2013 Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the circulation and lymphoid tissue, splenic marginal zone B cells rapidly respond to blood-borne ...
Montserrat Cols +2 more
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The Role of IL-4 Signaling in CD8+ Innate-Like Lymphocyte Development.
Blood, 2012Abstract Abstract 2161 The innate and adaptive arms of the immune system collaborate to protect the host against invading pathogens and perform immune surveillance against malignant transformation. As key effectors of the adaptive immune system, conventional T cells develop in the thymus and exit to the periphery as naïve
Shannon A. Carty +2 more
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Journal of Leukocyte Biology, 2016
Abstract Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined.
Kling, Jessica C., Blumenthal, Antje
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Abstract Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined.
Kling, Jessica C., Blumenthal, Antje
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Brain, Behavior, and Immunity, 2019
Stress is known to impede certain host defense mechanisms, including those governed by conventional T lymphocytes. However, whether innate-like T lymphocytes, such as invariant natural killer T (iNKT) and mucosa-associated invariant T (MAIT) cells, are impacted by stress is unclear.
Patrick T. Rudak +7 more
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Stress is known to impede certain host defense mechanisms, including those governed by conventional T lymphocytes. However, whether innate-like T lymphocytes, such as invariant natural killer T (iNKT) and mucosa-associated invariant T (MAIT) cells, are impacted by stress is unclear.
Patrick T. Rudak +7 more
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Blood, 2014
Abstract The generation of innate-like immune cells distinguishes fetal hematopoiesis from adult hematopoiesis, but the cellular mechanisms underlying differential cell production during development remain to be established. Specifically, whether differential lymphoid output arises as a consequence of discrete hematopoietic stem cell ...
Anna E Beaudin +3 more
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Abstract The generation of innate-like immune cells distinguishes fetal hematopoiesis from adult hematopoiesis, but the cellular mechanisms underlying differential cell production during development remain to be established. Specifically, whether differential lymphoid output arises as a consequence of discrete hematopoietic stem cell ...
Anna E Beaudin +3 more
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CCR6+ CD4+ Lymphocytes and Innate-like Lymphocytes Are Depleted in Ventilator Associated Pneumonia
D101. HOST DEFENSES AND IMMUNE CELLS, 2023M. Orlov +5 more
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