Results 241 to 250 of about 229,257 (276)
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]
Nature Reviews Immunology, 2013 Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Andrea Cerutti +2 more
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Consequence of the SLAM-SAP Signaling Pathway in Innate-like and Conventional Lymphocytes [PDF]
Immunity, 2007 Signaling lymphocytic activation molecule (SLAM) family receptors mediate important regulatory signals in immune cells, as a result of their exquisite ability to associate with members of the SLAM-associated protein (SAP) family of adaptors. As discussed
André Veillette +2 more
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Journal of Leukocyte Biology, 2017 Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity.
Antje Blumenthal
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Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE [PDF]
Cellular and Molecular Immunology, 2019 Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) in which the immune system damages the protective insulation surrounding the nerve fibers that project from neurons. A hallmark of MS and its animal model, experimental autoimmune encephalomyelitis (EAE), is autoimmunity against proteins of the myelin sheath ...
Luc Van Kaer, Chuan Wang, Guan Yang
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What rheumatologists need to know about innate lymphocytes [PDF]
Nature Reviews Rheumatology, 2016 Many rheumatic diseases are characterized by having an autoimmune background. Determining the mechanisms underlying autoimmunity is, therefore, important to further understand these diseases and to inform future lines of research aimed at developing new ...
George C Tsokos +2 more
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Innate and Innate-like Effector Lymphocytes in Health and Disease
The Journal of Immunology, 2022Abstract Lymphocytes can be functionally partitioned into subsets belonging to the innate or adaptive arms of the immune system. Subsets of innate and innate-like lymphocytes may or may not express Ag-specific receptors of the adaptive immune system, yet they are poised to respond with innate-like speed to pathogenic insults but lack ...
Luc Van Kaer +3 more
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Genomic and Transcriptional Mechanisms Governing Innate-like T Lymphocyte Development
The Journal of Immunology, 2022Abstract Innate-like lymphocytes are a subset of lymphoid cells that function as a first line of defense against microbial infection. These cells are activated by proinflammatory cytokines or broadly expressed receptors and are able to rapidly perform their effector functions owing to a uniquely primed chromatin state that is acquired as
Roxroy C Morgan, Barbara L Kee
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Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria
Cell, 2020 International audienceInborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease. We report a patient with mycobacterial disease due to inherited deficiency of the transcription factor T-bet.
Rui Yang +2 more
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A shared gene‐expression signature in innate‐like lymphocytes
Immunological Reviews, 2005Summary: Innate and adaptive immunities are the two major arms of the immune system, which rely on distinct cell types. These cells can be distinguished not only by the source of diversity for non‐self recognition, of germline or somatic origin, but also by their localization and the pattern and rates of response after encounter of antigenic triggers.
Tetsuya, Yamagata +2 more
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