Results 141 to 150 of about 154,668 (248)

Challenge Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory. [PDF]

Immunology
Pasco ST, Martín-Ruiz I, Araujo-Aris S, Barriales D, Castelo J, Egia-Mendikute L, Gonzalez M, Martin JE, Molina E, Mugica M, Palacios A, Seoane I, Gutiez N, Atondo E, Fernández ES, Oyanguren M, Jimenez-Lasheras B, Peña-Cearra A, Aransay AM, Palazon A, Pellón A, Abecia L, Rodriguez H, Elguezabal N, Anguita J.   +24 more
europepmc   +1 more source

Weight cycling induces innate immune memory in adipose tissue macrophages. [PDF]

Front Immunol, 2022
Caslin HL, Cottam MA, Piñon JM, Boney LY, Hasty AH.   +4 more
europepmc   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Epigenetic programming reshapes innate immune memory: decoding the molecular imprint of gouty inflammation. [PDF]

Front Pharmacol
Su W, Lu Y, Luo Z, Xiong H.
europepmc   +1 more source

Innate Immune Memory and the Host Response to Infection. [PDF]

J Immunol, 2022
Sherwood ER, Burelbach KR, McBride MA, Stothers CL, Owen AM, Hernandez A, Patil NK, Williams DL, Bohannon JK.   +8 more
europepmc   +1 more source

Innate immune memory of bronchial epithelial cells

, 2021
Les cellules épithéliales bronchiques (CEB) sont essentielles dans la défense immunitaire innée. La mémoire immunitaire innée, décrite chez les macrophages, est la capacité de ces cellules à mémoriser une première stimulation et de réagir de manière exacerbée ou réduite, lors d’un second contact avec un pathogène.
openaire   +1 more source

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

Advanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
wiley   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of TCE‐secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Editorial: Commending 20 years since the formal discovery of immune priming: the innate immune memory. [PDF]

Front Immunol
Contreras-Garduño J, Kurtz J.
europepmc   +1 more source