Results 161 to 170 of about 154,668 (248)

Hematopoietic stem cell a reservoir of innate immune memory. [PDF]

Front Immunol
Ruffinatto L, Groult Y, Iacono J, Sarrazin S, de Laval B.   +4 more
europepmc   +1 more source

Prophylactic and therapeutic insights into trained immunity: A renewed concept of innate immune memory. [PDF]

Hum Vaccin Immunother, 2022
Bindu S, Dandapat S, Manikandan R, Dinesh M, Subbaiyan A, Mani P, Dhawan M, Tiwari R, Bilal M, Emran TB, Mitra S, Rabaan AA, Mutair AA, Alawi ZA, Alhumaid S, Dhama K.   +15 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

<i>Salmonella</i> LVR01 triggers antagonistic two-armed innate immune memory that impacts on antitumor efficacy. [PDF]

Front Immunol
Chilibroste S, Dos Santos JC, Mónaco A, Joosten LAB, Moreno M, Chabalgoity JA.   +5 more
europepmc   +1 more source

β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages. [PDF]

J Immunol, 2021
Stothers CL, Burelbach KR, Owen AM, Patil NK, McBride MA, Bohannon JK, Luan L, Hernandez A, Patil TK, Williams DL, Sherwood ER.   +10 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

BCG-derived acellular membrane vesicles elicit antimycobacterial immunity and innate immune memory. [PDF]

Front Immunol
Yamaguchi T, Samukawa N, Matsumoto S, Shiota M, Matsumoto M, Nakao R, Hirayama S, Yoshida Y, Nishiyama A, Ozeki Y, Tomita S.   +10 more
europepmc   +1 more source

Developmental Stressors Induce Innate Immune Memory in Microglia and Contribute to Disease Risk. [PDF]

Int J Mol Sci, 2021
Carloni E, Ramos A, Hayes LN.
europepmc   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

Advanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Melissa A. Willman, Alexander Rabassa, Ashley L. Joubert, Tommaso Bo, Letizia Franco, Marzia Conte, Ana L. Anaya‐García, Gabrielle E. Rome, Rim Ouni, Henry J. Seaborne, Camden A. Caffey, Dora M. Berman, Junjun Zheng, Jesus Paez‐Mayorga, Corrine Ying Xuan Chua, Shu Hsia Chen, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Induction of Innate Immune Memory in LPS-Primed Microglial Cells by Water-Soluble Chitosan. [PDF]

Biomed Res Int
Thu VTA, Hoang TX, Park JK, Kim JY.
europepmc   +1 more source