Results 91 to 100 of about 1,613,203 (345)
Aging of the innate immune system [PDF]
Current Opinion in Immunology, 2010 The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like
Albert C, Shaw +4 more
openaire +2 more sources
The Innate Immune System in Acute and Chronic Wounds
Advances in wound care, 2016 Significance: This review article provides an overview of the critical roles of the innate immune system to wound healing. It explores aspects of dysregulation of individual innate immune elements known to compromise wound repair and promote nonhealing ...
A. MacLeod, J. Mansbridge
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
lncRNAs Regulate Innate Immune Responses and Their Roles in Macrophage Polarization
Mediators of Inflammation, 2018 The innate immune system is the first line of defense against microbial pathogens. The activated innate immune system plays important roles in eliciting antimicrobial defenses.
Zhen Wang, Ying Zheng
doaj +1 more source
Prion Disease and the Innate Immune System
Viruses, 2012 Prion diseases or transmissible spongiform encephalopathies are a unique category of infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by misfolding of the cellular prion protein these disorders possess an infectious ...
Barry M. Bradford, Neil A. Mabbott
doaj +1 more source
Toll-like receptors in cerebral ischemic inflammatory injury [PDF]
, 2011 Cerebral ischemia triggers acute inflammation, which has been associated with an increase in brain damage. The mechanisms that regulate the inflammatory response after cerebral ischemia are multifaceted.
Yan-Chun Wang, Sen Lin, Qing-Wu Yang
core +1 more source
The Innate Immune System and Transplantation [PDF]
Cold Spring Harbor Perspectives in Medicine, 2013 The sensitive and broadly reactive character of the innate immune system makes it liable to activation by stress factors other than infection. Thermal and metabolic stresses experienced during the transplantation procedure are sufficient to trigger the innate immune response and also augment adaptive immunity in the presence of foreign antigen on the ...
Farrar, Conrad A +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Innate Immune Sensing by Cells of the Adaptive Immune System
Frontiers in Immunology, 2020 Sensing of microbes or of danger signals has mainly been attributed to myeloid innate immune cells. However, T and B cells also express functional pattern recognition receptors (PRRs).
Tanja Stögerer, Simona Stäger
doaj +1 more source
Stable States of Biological Organisms
, 2009 A novel model of biological organisms is advanced, treating an organism as a self-consistent system subject to a pathogen flux. The principal novelty of the model is that it describes not some parts, but a biological organism as a whole.
A. Lichtenberg +13 more
core +1 more source