Results 91 to 100 of about 934,612 (346)
Regulation of the innate immune response in rheumatoid arthritis
Frontiers in ImmunologyRheumatoid arthritis (RA) is a common inflammatory joint disorder characterized by progressive joint destruction, leading to painful deformity and limited mobility, for which there is currently no effective cure.
Aikeremujiang Muheremu +5 more
doaj +1 more source
Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in
mBio, 2018 Upon pathogen infection, the nervous system regulates innate immunity to confer coordinated protection to the host. However, the precise mechanisms of such regulation remain unclear.
Durai Sellegounder +4 more
doaj +1 more source
Potential role of gut microbiota in induction and regulation of innate immune memory [PDF]
, 2019 The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity.
Agrewala, Javed N +4 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Prion Disease and the Innate Immune System
Viruses, 2012 Prion diseases or transmissible spongiform encephalopathies are a unique category of infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by misfolding of the cellular prion protein these disorders possess an infectious ...
Barry M. Bradford, Neil A. Mabbott
doaj +1 more source
hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke
Frontiers in Immunology, 2020 Innate immune memory is a part of the innate immune system that facilitates the elimination of pathogens. However, it may exacerbate neuropathology. In this study, we found that innate immune memory is detrimental in stroke, because it promotes the acute
Yi-wei Feng +17 more
doaj +1 more source
Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis
Mediators of Inflammation, 2021 Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature.
Rodolfo Kölliker Frers +6 more
doaj +1 more source
Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs. [PDF]
, 2009 BackgroundThe human innate immune system uses a system of extracellular Toll-like receptors (TLRs) and intracellular Nod-like receptors (NLRs) to match the appropriate level of immune response to the level of threat from the current environment.
Godzik, Adam, Istomin, Andrei Y
core +4 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system [PDF]
, 2022 Mouhita Humayun +7 more
openalex +1 more source