Results 41 to 50 of about 12,901 (262)
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation
Mediators of Inflammation, 2016 Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
Kathleen L. McCoy
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Planarians (Platyhelminthes)—An Emerging Model Organism for Investigating Innate Immune Mechanisms
Frontiers in Cellular and Infection Microbiology, 2021 An organism responds to the invading pathogens such as bacteria, viruses, protozoans, and fungi by engaging innate and adaptive immune system, which functions by activating various signal transduction pathways. As invertebrate organisms (such as sponges,
Luis Johnson Kangale +9 more
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Systems integration of innate and adaptive immunity [PDF]
Vaccine, 2015 The pathogens causing AIDS, malaria, and tuberculosis have proven too complex to be overcome by classical approaches to vaccination. The complexities of human immunology and pathogen-induced modulation of the immune system mandate new approaches to vaccine discovery and design.
Daniel E. Zak, Alan Aderem
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FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Systems Biology and Innate Immunity
Journal of Innate Immunity, 2013 The innate immune system is the first line of host defense against invading microorganisms and is essential for maintenance of host health. The innate immune response is largely mediated by soluble host factors—such as complement—and phagocytic leukocytes.
Frank R. DeLeo, Scott D. Kobayashi
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Recognition of herpesviruses by the innate immune system [PDF]
Nature Reviews Immunology, 2011 Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses that replicate in the nucleus, are initially recognized during cellular
Paludan, Soren R. +3 more
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Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Innate Pathways of Immune Activation in Transplantation
Journal of Transplantation, 2010 Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells.
Todd V. Brennan +2 more
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Viruses, 2020 Bovine Viral Diarrhea Virus (BVDV) fetal infections occur in two forms; persistent infection (PI) or transient infection (TI), depending on what stage of gestation the fetus is infected.
Katie J. Knapek +6 more
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