Results 121 to 130 of about 604,934 (370)

Dendritic Cells for Real-Time Anomaly Detection [PDF]

open access: yesarXiv, 2010
Dendritic Cells (DCs) are innate immune system cells which have the power to activate or suppress the immune system. The behaviour of human of human DCs is abstracted to form an algorithm suitable for anomaly detection. We test this algorithm on the real-time problem of port scan detection.
arxiv  

Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]

open access: yes, 2007
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Botto, M.   +3 more
core  

Subversion of host innate immunity by uropathogenic Escherichia coli [PDF]

open access: yes, 2016
Uropathogenic Escherichia coli (UPEC) cause the majority of community-onset urinary tract infections (UTI) and represent a major etiologic agent of healthcare-associated UTI.
Cavalieri   +5 more
core   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Encapsulation and Melanization Are Not Correlated to Successful Immune Defense Against Parasitoid Wasps in Drosophila melanogaster

open access: yesCells
Parasitoid elimination in Drosophila melanogaster involves special hemocytes, called lamellocytes, which encapsulate the eggs or larvae of the parasitoid wasps. The capsules are melanized, and metabolites of the melanization reaction may play a potential
Lilla B. Magyar   +2 more
doaj   +1 more source

Interferon Lambda Genetics and Biology in Regulation of Viral Control

open access: yesFrontiers in Immunology, 2017
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Emily A. Hemann, Michael Gale, Ram Savan
doaj   +1 more source

Detecting Anomalous Process Behaviour using Second Generation Artificial Immune Systems [PDF]

open access: yesarXiv, 2010
Artificial Immune Systems have been successfully applied to a number of problem domains including fault tolerance and data mining, but have been shown to scale poorly when applied to computer intrusion detec- tion despite the fact that the biological immune system is a very effective anomaly detector.
arxiv  

The critical role of innate immunity in kidney transplantation [PDF]

open access: yes, 2016
For a long time now, kidney transplant rejection has been considered the consequence of either cellular or antibody-mediated reaction as a part of adaptive immunity response. The role of innate immunity, on the other hand, had been unclear for many years
C. Ponticelli   +2 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Artificial Immune Systems Tutorial [PDF]

open access: yesarXiv, 2008
The biological immune system is a robust, complex, adaptive system that defends the body from foreign pathogens. It is able to categorize all cells (or molecules) within the body as self-cells or non-self cells. It does this with the help of a distributed task force that has the intelligence to take action from a local and also a global perspective ...
arxiv  

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