Results 121 to 130 of about 971,833 (308)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes

, 2017
Arata Itoh, William M Ridgway Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA Abstract: Type 1 diabetes (T1D) is characterized by specific destruction of pancreatic insulin-producing ...
Itoh A, Ridgway WM
core  

Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]

, 2007
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Brown, JS, Brown, J.S., Yuste, J., Botto, M., Bottoms, SE, Bottoms, S.E., Yuste, J, Botto, M   +7 more
core  

Pentraxins in humoral innate immunity

, 2012
Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm.
G. Garlanda, B. Bottazzi, A. Mantovani, S. Valentino, A. Inforzato   +4 more
core   +1 more source

Molecular insights on the proangiogenic effects of VEGF like growth factor derived from horseshoe crab perivitelline fluid

Scientific Reports
The current study investigated the proangiogenic effects of fraction VII of perivitelline fluid (hscPVF-VEGF) obtained from the late-stage embryos of Indian horseshoe crab (Tachypleus gigas; Müller) using human umbilical cord tissue-derived MSCs (hUCMSCs)
K. G. Aghila Rani, Hrishikesh Pandit, Rambhadur Subedi, Sayli Otiv-Pandit, Anil Bankati Jogdand, Hajra Gupta, Prayagraj Fandilolu, Sushama Rokade, Susan Idicula-Thomas, Anil Chatterji, Taruna Madan   +10 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Turning the Tables: Loss of Adaptive Immunity Reverses Sex Differences in Tuberculosis

Sex-based differences in innate immunity may play a crucial role in susceptibility to and progression of tuberculosis (TB), a disease that disproportionately affects men.
Lars Eggers, David Hertz, Bianca E. Schneider, Linda von Borstel, Hanna Lotter, Torsten Goldmann   +5 more
core   +1 more source

Signal transduction pathways that function in both development and innate immunity.

, 2010
C. elegans is developing in importance as a model for innate immunity. Several signaling pathways are known to be required for immune responses to a diverse range of pathogens, including the insulin signaling, p38 MAP kinase and transforming growth ...
Gravato-Nobre, M.J., Hodgkin, J., Partridge, F.A.   +2 more
core   +1 more source

Unlocking the potential for microbiome‐based therapeutics to address the sustainable development goal of good health and wellbeing

Microbial Biotechnology
Recent years have witnessed major advances and an ever‐growing list of healthcare applications for microbiome‐based therapeutics. However, these advances have disproportionately targeted diseases common in high‐income countries (HICs).
Emily L. Gulliver, Sara K. Di Simone, Michelle Chonwerawong, Samuel C. Forster   +3 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source