Results 211 to 220 of about 191,579 (251)
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2020
Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
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Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
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Immunity without innate lymphoid cells
Nature Immunology, 2016A cohort of immunodeficient children lead near-normal lives after bone marrow transplantation, despite a profound deficiency of innate lymphoid cells (ILCs).
Weinkove, Robert +2 more
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Development of innate lymphoid cells
Nature Immunology, 2016Innate lymphoid cells (ILCs) are a family of immune effector cells that have important roles in host defense, metabolic homeostasis and tissue repair but can also contribute to inflammatory diseases such as asthma and colitis. These cells can be categorized into three groups on the basis of the transcription factors that direct their function and the ...
Erin C, Zook, Barbara L, Kee
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Innate Lymphoid Cells in Cancer
Cancer Immunology Research, 2015AbstractThe world of lymphocytes has recently expanded. A group of cells, innate lymphoid cells (ILC), has been defined. It includes lymphoid cells that have been known for decades, such as natural killer (NK) cells and lymphoid tissue–inducer (LTi) cells. NK cells recognize a vast array of tumor cells, which they help to eliminate through cytotoxicity
B. Vallentin +9 more
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Innate lymphoid cells in atherosclerosis
European Journal of Pharmacology, 2017The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions.
Daniel, Engelbertsen, Andrew H, Lichtman
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The Innate Lymphoid Cell Precursor
Annual Review of Immunology, 2016The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing ...
Isabel E, Ishizuka +3 more
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Innate lymphoid cells and asthma
Journal of Allergy and Clinical Immunology, 2014Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype characterized by TH2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes, such as asthma associated with exposure to air pollution, infection, or obesity, that
Sanhong, Yu +4 more
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Plasticity of innate lymphoid cell subsets
Nature Reviews Immunology, 2020Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can be categorized into five subsets with defined phenotypes and functional profiles, but they also have the ability to adapt to local environmental cues by changing these ...
Suzanne M. Bal +2 more
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Early Development of Innate Lymphoid Cells
2022Innate lymphoid cells (ILCs) are transcriptionally and functionally similar to T cells but lack adaptive antigen receptors. They play critical roles in early defense against pathogens. In this review, we summarize recent discoveries of ILC progenitors and discuss possible mechanisms that separate ILCs from T cells.
Ding, Yi +3 more
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Immunophenotyping of Human Innate Lymphoid Cells
2019In the last years, the family of innate lymphocytes has been growing following the discovery of innate lymphoid cells (ILCs). ILCs are lymphocytes able to rapidly produce a wide range of soluble mediators in an antigen-independent fashion. So far, three main subsets of ILCs have been discovered, ILC1, ILC2, and ILC3, expressing respectively the ...
Trabanelli, Sara +2 more
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