Regulation of inner nuclear membrane associated protein degradation [PDF]
Nucleus, 2019 The nucleus is enclosed by a double-membrane structure, the nuclear envelope, which separates the nucleoplasm from the cytoplasm. The outer nuclear membrane is continuous with the endoplasmic reticulum (ER), whereas the inner nuclear membrane (INM) is a ...
Bailey Koch, Hong-Guo Yu
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SUMOylation at the inner nuclear membrane facilitates nuclear envelope biogenesis during mitosis. [PDF]
J Cell Biol, 2023 Saik et al. show that multiple yeast inner nuclear membrane (INM) proteins are SUMOylated during mitosis. These INM-specific SUMOylation events support mitotic nuclear membrane expansion by increasing INM phosphatidic acid levels, temporally coupling ...
Saik NO +5 more
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Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function [PDF]
eLife, 2022 Nuclear architecture and functions depend on dynamic interactions between nuclear components (such as chromatin) and inner nuclear membrane (INM) proteins. Mutations in INM proteins interfering with these interactions result in disease.
Logesvaran Krshnan +6 more
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The Diverse Cellular Functions of Inner Nuclear Membrane Proteins. [PDF]
Cold Spring Harb Perspect Biol, 2021 The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear membrane and the contiguous peripheral ER, the inner nuclear membrane (INM) houses a ...
Pawar S, Kutay U.
europepmc +4 more sources
Norepinephrine activates β1 -adrenergic receptors at the inner nuclear membrane in astrocytes. [PDF]
Glia, 2022 Norepinephrine exerts powerful influences on the metabolic, neuroprotective and immunoregulatory functions of astrocytes. Until recently, all effects of norepinephrine were believed to be mediated by receptors localized exclusively to the plasma membrane.
Benton KC +15 more
europepmc +2 more sources
The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy. [PDF]
Cancer Metastasis Rev, 2022 Despite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account for 30% of worldwide deaths.
Rose M +4 more
europepmc +2 more sources
The ESCRT machinery directs quality control over inner nuclear membrane architecture. [PDF]
Cell Rep, 2022 SUMMARY The late-acting endosomal sorting complex required for transport (ESCRT) machinery has been implicated in facilitating the resealing of the nuclear envelope (NE) after mitosis, enabling compartmentalization of the genome away from the cytoplasm ...
Shankar R +4 more
europepmc +2 more sources
Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome. [PDF]
J Cell Biol, 2021 Mechanisms that turnover components of the nucleus and inner nuclear membrane (INM) remain to be fully defined. We explore how components of the INM are selected by a cytosolic autophagy apparatus through a transmembrane nuclear envelope-localized cargo ...
Chandra S +6 more
europepmc +2 more sources
Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis
bioRxiv, 2022 Nuclear envelope (NE) expansion must be controlled to maintain nuclear shape and function. The nuclear membrane expands massively during ‘closed’ mitosis, enabling chromosome segregation within an intact NE. Phosphatidic acid (PA) and diacylglycerol (DG)
Foo S +3 more
europepmc +2 more sources
Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner. [PDF]
J Cell Biol, 2021 Sołtysik et al. show that the inner nuclear membrane of nonhepatocytes harbors triglyceride synthesis enzymes and generates nuclear lipid droplets (LDs).
Sołtysik K +6 more
europepmc +2 more sources